Author | Katz, Naftale | |
Author | Couto, Flávia Fernanda Bubulo | |
Author | Araújo, Neusa | |
Access date | 2018-12-19T11:48:26Z | |
Available date | 2018-12-19T11:48:26Z | |
Document date | 2013 | |
Citation | KATZ, Naftale; COUTO, Flávia Fernanda Bubulo; ARAUJO, Neusa. Imatinib activity on Schistosoma mansoni. Mem. Inst. Oswaldo Cruz, v. 108, n. 7, p. 850-853, 2013 | pt_BR |
ISSN | 0074-0276 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/30689 | |
Language | eng | pt_BR |
Publisher | Fundação Oswaldo Cruz | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Esquistossomosse | pt_BR |
Subject in Portuguese | quimioterapia | pt_BR |
Subject in Portuguese | imatinibe | pt_BR |
Title | Imatinib activity on Schistosoma mansoni. | pt_BR |
Type | Article | pt_BR |
Abstract | Imatinib, a drug used for treatment of human chronic myeloid leukaemia, due to its activity against protein kinases, has been also evaluated in vitro against Schistosoma mansoni showing high schistosomicidal activity. In the present experiments imatinib activity in vitro was confirmed at the doses of 25 µM, 50 µM and 100 µM. The first drug activity observed with the lower dose was interruption of egg-laying and with the higher dosages was the death of the worms. In mice infected with S. mansoni no activity was found even with 1,000 mg/kg/day, 500 mg/kg/day, single oral dose or when administered for three consecutive days. This is another example of the difference of results related to in vitro and in vivo trials using S. mansoni worms. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brasil/Academia Mineira de Medicina. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brasil | pt_BR |
Subject | schistosomiasis | pt_BR |
Subject | chemotherapy | pt_BR |
Subject | imatinib | pt_BR |
e-ISSN | 10.1590/0074-0276130207 | |