Author | Martins, Flaviano dos Santos | |
Author | Vieira, Angélica Thomaz | |
Author | Elian, Samir de Deus | |
Author | Arantes, Rosa Maria Esteves | |
Author | Tiago, Fabiana da Conceição Pereira | |
Author | Sousa, Lirlândia Pires de | |
Author | Araújo, Helena R.C. | |
Author | Pimenta, Paulo Filemon Paolucci | |
Author | Bonjardim, Cláudio Antonio | |
Author | Nicoli, Jacques Robert | |
Author | Teixeira, Mauro Martins | |
Access date | 2018-12-21T18:27:26Z | |
Available date | 2018-12-21T18:27:26Z | |
Document date | 2013 | |
Citation | MARTINS, Flaviano dos Santos et al. Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice. Microbes Infect., v. 15, n. 4, p. 270-279, 2013 | pt_BR |
ISSN | 1286-4579 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/30739 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Saccharomyces boulardii | pt_BR |
Subject in Portuguese | Salmonella enterica serovar Typhimurium | pt_BR |
Subject in Portuguese | translocação bacteriana | pt_BR |
Subject in Portuguese | citocinas | pt_BR |
Title | Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.micinf.2012.12.007 | |
Abstract | Growing evidences suggest that Saccharomyces boulardii (SB) is efficacious against bacterial infections and inflammatory bowel diseases. This study investigated the effects of treatment with SB provided in a murine model of typhoid fever. Mice were divided into two groups: (1) control animals challenged with Salmonella Typhimurium (ST), and (2) animals receiving SB, and then challenged with ST. At days 0, 1, 5, 10 and 15 post-challenge, animals were euthanized and tissues collected to analyze bacterial translocation, cytokines, signaling pathways and histological analysis. Survival rate and animal weight were also evaluated. Treatment with SB increased survival rate and inhibited translocation of bacteria after ST challenge. Histological data showed that SB also protected mice against liver damage induced by ST. SB decreased levels of inflammatory cytokines and activation of mitogen-activated protein kinases (p38, JNK and ERK1/2), phospho-IκB, p65-RelA, phospho-jun and c-fos in the colon, signal pathways involved in the activation of inflammation induced by ST. Further experiments revealed that probiotic effects were due, at least in part, to the binding of ST to the yeast. Such binding diminishes ST translocation, resulting in decreased activation of signaling pathways which lead to intestinal inflammation in a murine model of typhoid fever. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Faculdade de Fármacia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Entomologia Médica. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Entomologia Médica. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil | pt_BR |
Subject | Saccharomyces boulardii | pt_BR |
Subject | Salmonella enterica serovar Typhimurium | pt_BR |
Subject | Bacterial translocation | pt_BR |
Subject | Cytokines | pt_BR |
Subject | Mitogen-activated protein kinases | pt_BR |