Author | Coutinho, Leticia | |
Author | Ferreira, Marcelo Alves | |
Author | Cosson, Alain | |
Author | Batista, Marcos Meuser | |
Author | Batista, Denise da Gama Jaén | |
Author | Minoprio, Paola | |
Author | Degrave, Win M. | |
Author | Berneman, Armand | |
Author | Soeiro, Maria Nazaré C. | |
Access date | 2019-01-10T15:19:10Z | |
Available date | 2019-01-10T15:19:10Z | |
Document date | 2009 | |
Citation | COUTINHO, Leticia et al. Inhibition of Trypanosoma cruzi proline racemase affects host-parasite interactions and the outcome of in vitro infection. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 104, n. 8, p. 1055-1062, Dec. 2009. | pt_BR |
ISSN | 0074-0276 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/30969 | |
Language | eng | pt_BR |
Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz | pt_BR |
Rights | open access | |
Subject in Portuguese | Trypanosoma cruzi | pt_BR |
Subject in Portuguese | Prolina racemase | pt_BR |
Subject in Portuguese | Inibição enzimática | pt_BR |
Subject in Portuguese | Interação parasita-hospedeiro | pt_BR |
Title | Inhibition of Trypanosoma cruzi proline racemase affects host-parasite interactions and the outcome of in vitro infection | pt_BR |
Type | Article | |
Abstract | Proline racemase is an important enzyme of Trypanosoma cruzi and has been shown to be an effective mitogen for B cells, thus contributing to the parasite’s immune evasion and persistence in the human host. Recombinant epimastigote parasites overexpressing TcPRAC genes coding for proline racemase present an augmented ability to differentiate into metacyclic infective forms and subsequently penetrate host-cells in vitro. Here we demonstrate that both anti T. cruzi proline racemase antibodies and the specific proline racemase inhibitor pyrrole-2-carboxylic acid significantly affect parasite infection of Vero cells in vitro. This inhibitor also hampers T. cruzi intracellular differentiation. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Institut Pasteur. Laboratoire d’Immunobiologie des infections à Trypanosoma. Département d’Immunologie. Paris, France. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Institut Pasteur. Laboratoire d’Immunobiologie des infections à Trypanosoma. Département d’Immunologie. Paris, France. | pt_BR |
Affilliation | undação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Institut Pasteur. Laboratoire d’Immunobiologie des infections à Trypanosoma. Département d’Immunologie. Paris, France. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Trypanosoma cruzi | pt_BR |
Subject | Host-parasite interaction | pt_BR |
Subject | Enzyme inhibition | pt_BR |
Subject | Proline racemase | pt_BR |
e-ISSN | 1678-8060 | |