Author | Camara, Edmundo José Nassri | |
Author | Mendonca, Vitor Rosa Ramos | |
Author | Souza, Ligia C. L. | |
Author | Carvalho, Juliana S. | |
Author | Lessa, Rudá Alves | |
Author | Gatto, Ramon | |
Author | Barreto, Luan Oliveira | |
Author | Chiacchio, Giulianna | |
Author | Amarante, Eduardo | |
Author | Cunha, Monaliza | |
Author | Silva, Luis S. Alves | |
Author | Guimarães, Benelson A. C. | |
Author | Barral Netto, Manoel | |
Access date | 2019-01-23T17:54:22Z | |
Available date | 2019-01-23T17:54:22Z | |
Document date | 2019 | |
Citation | CAMARA, E. J. N. et al. Elevated IL-17 levels and echocardiographic signs of preserved myocardial function in benznidazole-treated individuals with chronic Chagas' disease. International Journal of Infectious Diseases, v. 79, p. 123-130, 2019. | pt_BR |
ISSN | 1201-9712 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/31267 | |
Sponsorship | Conselho Nacional de Pesquisa e Tecnologia (CNPq), Brazil. VRRM and LCLS were supported by CNPq. | pt_BR |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Doença de Chagas | pt_BR |
Subject in Portuguese | Tratamento com benznidazol | pt_BR |
Subject in Portuguese | Resposta imune | pt_BR |
Subject in Portuguese | Citocinas | pt_BR |
Subject in Portuguese | Ecocardiográfico | pt_BR |
Subject in Portuguese | Doppler tecidual | pt_BR |
Title | Elevated IL-17 levels and echocardiographic signs of preserved myocardial function in benznidazole-treated individuals with chronic Chagas' disease | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.ijid.2018.11.369 | |
Abstract | The immunological and clinical impact of trypanocidal treatment in chronic Chagas' disease (CCD) is unclear. Methodology and findings: Several cytokines were measured in plasma of 66 patients with CCD. Thirtythree
patients had been previously treated with benznidazole and 33 had never been treated. The treated
group exhibited higher levels of IL-17 (median 142.45
1.22 pg/ml, P = 0.025), which was the only one
significantly associated with Bz treatment, especially after adjusting for time of disease and NYHA class
(P = 0.024; OR 1.006, 95% CI 1.001-1.010). Compared to untreated patients, the treated group exhibited
higher median values of mitral annular E’ lateral (13.0
10.0 cm/s, P = 0.038), S’ infero-lateral
(8.9
7.6 cm/s, P = 0.013), S’ septal (8.5
7.4 cm/s, P = 0.034), mean S’ (9.0
7.9 cm/s, P = 0.013) and
tricuspid annular S’ (13.3
11.1 cm/s, P = 0.001) and lower values of E/E’ septal (7.2
9.5 cm/s, P = 0.049).
After adjustment for time of disease and NYHA class, S’ infero-lateral (P = 0.031), mean S’ (P = 0.049) and S’
tricuspid (P = 0.024) persisted as significantly associated with treatment.
Conclusion: The present
findings suggest that the group of CCD patients treated with Bz displayed
increased plasma levels of IL-17 and preserved myocardial function, reinforcing the idea that Bz
treatment may be beneficial. | pt_BR |
Affilliation | Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Universidade Federal da Bahia. Complexo Hospitalar Professor Edgard Santos. Unidade Docente Assistencial de Cardiologia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | pt_BR |
Affilliation | Faculdade de Tecnologia e Ciências. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | pt_BR |
Affilliation | Faculdade de Tecnologia e Ciências. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Unidade Docente Assistencial de Cardiologia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Unidade Docente Assistencial de Cardiologia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Climecar. Clinica de Cardiologia. Itaberaba, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Investigação em Imunologia. São Paulo, SP, Brasil. | pt_BR |
Subject | Chagas’ disease | pt_BR |
Subject | Benznidazol treatment | pt_BR |
Subject | Immune response | pt_BR |
Subject | Cytokines | pt_BR |
Subject | Echocardiographic | pt_BR |
Subject | Tissue Doppler | pt_BR |
xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |