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COMPARATIVE ANALYSIS OF THE INTRACEREBRAL MOUSE PROTECTION TEST AND SEROLOGICAL METHOD FOR POTENCY ASSAYS OF PERTUSSIS COMPONENT IN DTP VACCINE
Pertussis whole cell
Enzyme-linked immunosorbent assay
Intracerebral mouse protection test
Autor
Afiliación
Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
Instituto Butantan. São Paulo, SP, Brasil.
Instituto Butantan. São Paulo, SP, Brasil.
Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
Instituto Butantan. São Paulo, SP, Brasil.
Instituto Butantan. São Paulo, SP, Brasil.
Resumen en ingles
The aim of this study was to compare the PSPT standardized in-house as an alternative to MPT for potency assays of pertussis component. Statistical analyses have showed similar pertussis potency values when PSPT was compared to MPT. Significant correlation between the potency results obtained by in vivo and in vitro assays was also been observed. Results by PSPT have demonstrated reproducibility and accuracy for potency pertussis control and this approach has been considered promising for use at least during the steps of production.
Palabras clave en portugues
DTP vaccinePertussis whole cell
Enzyme-linked immunosorbent assay
Intracerebral mouse protection test
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