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A MOLECULAR STUDY ON THE EVOLUTION OF A SUBTYPE B VARIANT FREQUENTLY FOUND IN BRAZIL
Subtipo B
Evolução molecular
Origem
Variante GWGR
Pressão seletiva
Brasil
Subtype B
GWGR variant
Molecular evolution
Origin
Selective pressure
Brazil
Afiliación
Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Biodiversidade Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ. Brasil.
Resumen en ingles
In spite of the remarkable diversity of HIV-1 env genes, several amino acids are extremely conserved, probably due to functional constraints. One example is the proline found at the second position of the GPGR motif. Several viruses, however, bear substitutions at this site, for instance, GWGR subtype B variant. GWGR viruses are described in Brazil since the beginning of the epidemics, but the extent of their dispersion or the geographical origin of the variant remains unknown. In the present study, phylogenetic trees were constructed in order to study the origin and spread of this variant. All GWGR sequences as well as a subset of subtype B sequences available were included in the analyses. Analyses of differential selection were also performed on GWGR and non-GWGR sequences in order to unveil evolutionary novelties due to the action of positive selection. Although the GWGR variant was found at least in 23 countries, its expansion probably has a single origin, and Brazil is the epicenter.
Palabras clave en portugues
HIV-1Subtipo B
Evolução molecular
Origem
Variante GWGR
Pressão seletiva
Brasil
Palabras clave en ingles
HIV-1Subtype B
GWGR variant
Molecular evolution
Origin
Selective pressure
Brazil
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