Author | Carvalho, Paulo C. | |
Author | Junqueira, Magno | |
Author | Valente, Richard H. | |
Author | Domont, Gilberto B. | |
Access date | 2019-03-28T14:49:04Z | |
Available date | 2019-03-28T14:49:04Z | |
Document date | 2008 | |
Citation | CARVALHO, Paulo C. et al. Caititu: A tool to graphically represent peptide sequence coverage and domain distribution. Journal of Proteomics, v. 71, p.486-489, 2008. | pt_BR |
ISSN | 1874-3919 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/32269 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Proteômica | pt_BR |
Subject in Portuguese | Ferramenta de software | pt_BR |
Subject in Portuguese | Toxinologia | pt_BR |
Subject in Portuguese | Caititu | pt_BR |
Subject in Portuguese | Cobertura de proteínas | pt_BR |
Title | Caititu: a tool to graphically represent peptide sequence coverage and domain distribution | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.jprot.2008.06.015 | |
Abstract | Here we present Caititu, an easy-to-use proteomics software to graphically represent peptide sequence coverage and domain distribution for different correlated samples (e.g. originated from 2D gel spots) relatively to the full-sequence of the known protein they are related to. Although Caititu has a broad applicability, we exemplify its usefulness in Toxinology using snake venom as a model. For example, proteolytic processing may lead to inactivation or loss of domains. Therefore, our proposed graphic representation for peptides identified by two dimensional electrophoresis followed by mass spectrometric identification of excised spots can aid in inferring what kind of processing happened to the toxins, if any. Caititu is freely available to download at: http://pcarvalho.com/things/caititu. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. COPPE. Programa de Engenharia de Sistemas e Ciência da Computação. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Max Planck Institute of Molecular Cell Biology and Genetics. Dresden, Germany. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro.Instituto de Química. Laboratório de Química de Proteína. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Proteomics | pt_BR |
Subject | Software tool | pt_BR |
Subject | Toxinology | pt_BR |
Subject | Caititu | pt_BR |
Subject | Protein coverage | pt_BR |
e-ISSN | 1876-7737 | |
Embargo date | 2022-01-01 | |