Author | Falcoff, R | |
Author | Barral Netto, Manoel | |
Author | Stiffels, C | |
Author | Bouthilliers, Y | |
Author | Barral, Aldina Maria Prado | |
Author | Freitas, Luiz Antonio Rodrigues de | |
Author | Mevels, J. C | |
Author | Moutons, D | |
Access date | 2019-03-29T12:45:42Z | |
Available date | 2019-03-29T12:45:42Z | |
Document date | 1991 | |
Citation | FALCOFF, R. et al. Variations in susceptibility to Leishmania amazonensis infection in lines of mice selected for high or low immunoresponsiveness. Parasite Immunology, v. 13, p. 639-647, 1991. | pt_BR |
ISSN | 0141-9838 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/32288 | |
Description | Barral Netto, M.; Barral, A. M. P.; Freitas, Luiz Antônio Rodrigues de. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
“Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
Language | eng | pt_BR |
Publisher | Wiley | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Leishmania amazonensis | pt_BR |
Subject in Portuguese | Genética de resistência | pt_BR |
Subject in Portuguese | Alta e baixa imunorresponsividade | pt_BR |
Subject in Portuguese | Camundongos | pt_BR |
Subject in Portuguese | Leishmania | pt_BR |
Title | Variations in susceptibility to Leishmania amazonensis infection in lines of mice selected for high or low immunoresponsiveness. | pt_BR |
Type | Article | pt_BR |
Abstract | The degree of resistance to a local Leishmania amazonensis challenge
has been compared in lines of mice obtained by selective breeding for high or low
immunoresponsiveness: High and Low antibody responder mice of Selections I
and I1 (HI, HI, and L1, Lll lines) and high and low responder mice to T mitogen
PHA (Hi/PHA and Lo/PHA). The aim of this preliminary study was to focus
attention on genetic differences related with well defined immune characteristics.
Clear-cut results were obtained, both Hi and HII mice developed large and
disseminating lesions, the rate of symptom aggravation being faster in HI^, while
L1 and LI1 proved resistant to parasites, only small and transient lesions being
observed for them during a 150 days follow up. The outcome of infection also
differs in Hi/PHA and Lo/PHA mice, Hi/PHA having a resistant and Lo/PHA a
susceptible phenotype. | pt_BR |
Affilliation | INSERM. Institut Curie. Section de Biologie. Paris, France. | pt_BR |
Affilliation | Hospital Universitario Prof. Edgard Santos. Salvador, BA, Brasil. | pt_BR |
Affilliation | Institut Curie. Section de Biologie. Paris, France. | pt_BR |
Affilliation | Institut Curie. Section de Biologie. Paris, France. | pt_BR |
Affilliation | Hospital Universitario Prof. Edgard Santos. Salvador, BA, Brasil. | pt_BR |
Affilliation | Hospital Universitario Prof. Edgard Santos. Salvador, BA, Brasil. | pt_BR |
Affilliation | Institut Curie. Section de Biologie. Paris, France. | pt_BR |
Affilliation | Institut Curie. Section de Biologie. Paris, France. | pt_BR |
Subject | Leishmania amazonensis | pt_BR |
Subject | Genetics of resistance | pt_BR |
Subject | High and Low immunoresponsiveness | pt_BR |
Subject | Mice | pt_BR |
Subject | Leishmania | pt_BR |