Author | Botelho, Sílvia M. | |
Author | Ferreira, Renata C. | |
Author | Reis, Nádia R. S. | |
Author | Kozlowski, Aline G. | |
Author | Carneiro, Megmar A. S. | |
Author | Teles, Sheila A. | |
Author | Yoshida, Clara F. T. | |
Author | Martins, Regina M. B. | |
Access date | 2019-04-04T15:24:38Z | |
Available date | 2019-04-04T15:24:38Z | |
Document date | 2008 | |
Citation | BOTELHO, Sílvia M. et al. Epidemiological aspects of hepatitis C virus infection among renal transplant recipients in Central Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 5, p. 472-476, Aug. 2008. | pt_BR |
ISSN | 0074-0276 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/32371 | |
Language | eng | pt_BR |
Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | VÍrus da Hepatite C | pt_BR |
Subject in Portuguese | Fatores de Risco | pt_BR |
Subject in Portuguese | Prevalência | pt_BR |
Subject in Portuguese | Genótipos | pt_BR |
Subject in Portuguese | Receptores de transplante renal | pt_BR |
Title | Epidemiological aspects of hepatitis C virus infection among renal transplant recipients in Central Brazil | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/S0074-02762008000500011 | pt_BR |
Abstract | An investigation was conducted involving 255 renal transplant recipients in the state of Goiás, Central Brazil, to
determine the prevalence of hepatitis C virus (HCV), its risk factors, the genotypes involved, and the level of alanine
aminotransferase (ALT) present in the patients. All serum samples were tested for anti-HCV antibodies and HCV
RNA. Forty-one patients were anti-HCV and/or HCV RNA positive, resulting in an overall HCV infection prevalence
of 16.1% (95% CI: 11.9-21.3). A multivariate analysis of risk factors showed that a history of blood transfusions without
anti-HCV screening, the length of time spent on hemodialysis, and renal transplantation before 1994 are all associated
with HCV positivity. In HCV-positive patients, only 12.2% had ALT levels above normal. Twenty-eight samples were
genotyped as genotype 1, subtypes 1a (62.5%) and 1b (31.3%), and two samples (6.2%) were genotype 3, subtype 3a.
These data show a high prevalence of HCV infection and low ALT levels in the studied population. The risk factor
analysis findings emphasize the importance of public health strategies such as anti-HCV screening of candidate blood
and organ donors, in addition to the stricter adoption of hemodialysis-specific infection control measures. The present study also demonstrates that HCV genotype 1 (subtype 1a) is predominant in this population. | pt_BR |
Affilliation | Pontifícia Universidade Católica de Goiás. Goiânia, GO, Brasil / Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia, GO, Brasil. | pt_BR |
Affilliation | Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil / Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia, GO, Brasil. | pt_BR |
Affilliation | Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil / Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia, GO, Brasil. | pt_BR |
Affilliation | Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil / Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia, GO, Brasil. | pt_BR |
Affilliation | Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil./ Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia, GO, Brasil. | pt_BR |
Affilliation | Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil./ Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia, GO, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil./ Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia, GO, Brasil. | pt_BR |
Subject | Hepatitis C virus | pt_BR |
Subject | Renal transplant recipients | pt_BR |
Subject | Prevalence | pt_BR |
Subject | Risk factors | pt_BR |
Subject | ALT | pt_BR |
Subject | Genotypes | pt_BR |
DeCS | Alanina Transaminase | pt_BR |
e-ISSN | 1678-8060 | |