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2022-01-01
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- IOC - Artigos de Periódicos [12500]
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RETHINKING ISOLATED CLEFT PALATE: EVIDENCE OF OCCULT LIP DEFECTS IN A SUBSET OF CASES
Author
Affilliation
University of Pittsburgh. School of Dental Medicine. Center for Craniofacial and Dental Genetics. Pittsburgh, PA, USA / University of Yowa. Carver College of Medicine. Department of Psychiatry. Iowa City. Iowa, USA.
University of Pittsburgh. School of Dental Medicine. Center for Craniofacial and Dental Genetics. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Department of Oral Biology. Pittsburg, PA, USA..
University of Pittsburgh. School of Dental Medicine. Center for Craniofacial and Dental Genetics. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Department of Oral Biology. Pittsburg, PA, USA..
University of Pittsburgh. School of Dental Medicine. Department of Surgery. Division of Plastic Surgery. Pittsburgh, PA, USA.
Universidad Autónoma. Niño Jesús University Hospital. Department of Plastic Surgery. Madrid, Spain.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Estudo Colaborativo Latino-Americano de Malformações Congênitas. Rio de Janeiro, RJ, Brasil / Center for Medical Education and Clinical Investigation (CEMIC).Buenos Aires, Argentina.
Foundation for the Community Control of Hereditary Disease. Budapest, Hungary / Eötvös Loránd University. Department of Genetics. Budapest, Hungary.
University of Pittsburgh. School of Dental Medicine. Center for Craniofacial and Dental Genetics. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Department of Oral Biology. Pittsburg, PA, USA / University of Pittsburg, School of Dental Medicine. Department of Pediatric Dentistry. Pittisburg, PA, USA / University of Pittsburg. Graduate School of Public Health, Department of Human Genetics, Pittsburgh, PA, USA.
University of Pittsburgh. School of Dental Medicine. Center for Craniofacial and Dental Genetics. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Department of Oral Biology. Pittsburg, PA, USA / University of Pittsburg. School of Dental Medicine. Department of Pedriatic Dentistry. Pittsburg, PA, USA /University of Pittsburg. Graduate School of Public Health, Department of Human Genetics, Pittsburgh, PA, USA.
University of Pittsburgh. School of Dental Medicine. Center for Craniofacial and Dental Genetics. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Department of Oral Biology. Pittsburg, PA, USA / University of Pittsburg. Graduate School of Public Health, Department of Human Genetics, Pittsburgh, PA, USA / University of Pittsburg. School of Medicine. Department of Psychiatry. Pittsburg, PA, USA.
University of Pittsburgh. School of Dental Medicine. Center for Craniofacial and Dental Genetics. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Department of Oral Biology. Pittsburg, PA, USA..
University of Pittsburgh. School of Dental Medicine. Center for Craniofacial and Dental Genetics. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Department of Oral Biology. Pittsburg, PA, USA..
University of Pittsburgh. School of Dental Medicine. Department of Surgery. Division of Plastic Surgery. Pittsburgh, PA, USA.
Universidad Autónoma. Niño Jesús University Hospital. Department of Plastic Surgery. Madrid, Spain.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Estudo Colaborativo Latino-Americano de Malformações Congênitas. Rio de Janeiro, RJ, Brasil / Center for Medical Education and Clinical Investigation (CEMIC).Buenos Aires, Argentina.
Foundation for the Community Control of Hereditary Disease. Budapest, Hungary / Eötvös Loránd University. Department of Genetics. Budapest, Hungary.
University of Pittsburgh. School of Dental Medicine. Center for Craniofacial and Dental Genetics. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Department of Oral Biology. Pittsburg, PA, USA / University of Pittsburg, School of Dental Medicine. Department of Pediatric Dentistry. Pittisburg, PA, USA / University of Pittsburg. Graduate School of Public Health, Department of Human Genetics, Pittsburgh, PA, USA.
University of Pittsburgh. School of Dental Medicine. Center for Craniofacial and Dental Genetics. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Department of Oral Biology. Pittsburg, PA, USA / University of Pittsburg. School of Dental Medicine. Department of Pedriatic Dentistry. Pittsburg, PA, USA /University of Pittsburg. Graduate School of Public Health, Department of Human Genetics, Pittsburgh, PA, USA.
University of Pittsburgh. School of Dental Medicine. Center for Craniofacial and Dental Genetics. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Department of Oral Biology. Pittsburg, PA, USA / University of Pittsburg. Graduate School of Public Health, Department of Human Genetics, Pittsburgh, PA, USA / University of Pittsburg. School of Medicine. Department of Psychiatry. Pittsburg, PA, USA.
Abstract
Emerging research suggests that subepithelial defects of the
upper lip musculature are part of the phenotypic spectrum of
cleft lip and/or palate (CL/P) and may represent an occult,
subclinical manifestation of the anomaly. The present
study investigates whether similar occult lip defects are
present in individuals affected with isolated cleft palate (CP).
To this end, upper lip ultrasounds of 33 CP cases (12 males,
21 females) were evaluated retrospectively for the presence
of discontinuities (i.e., breaks) within the orbicularis oris
muscle (OOM). In four CP cases (2 males, 2 females), distinct
discontinuities of the OOM were identified. Of the remaining
CP individuals, 23 demonstrated normal lip morphology on
ultrasound (7 males, 16 females), while, in 6 cases (3 males,
3 females), a definitive evaluation was not possible. As CP
and CL/P are traditionally thought to be etiologically distinct,
these findings raise the possibility that some CP cases may be
misclassified. Such diagnostic errors could have important
implications for recurrence risk estimation and studies aimed
at discovering etiology.
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