Author | Kovacs, G. G. | |
Author | Pozza, E. L. | |
Author | Chimelli, L. C. | |
Author | Araújo, A. Q. C. | |
Author | Gabbai, A. A. | |
Author | Strobel, T. | |
Author | Glatzel, M. | |
Author | Aguzzi, A. | |
Author | Budka, H. | |
Access date | 2019-05-03T14:59:21Z | |
Available date | 2019-05-03T14:59:21Z | |
Document date | 2004 | |
Citation | KOVACS, Gabor G. et al. Creutzfeldt-Jakob disease and inclusion body myositis: abundant disease-associated prion protein in muscle. Annals of Neurology, v. 55, p. 121-125, 2004. | pt_BR |
ISSN | 0364-5134 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/32936 | |
Description | Abelardo de Queiroz Campos Araújo. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. | pt_BR |
Language | eng | pt_BR |
Publisher | Wiley | pt_BR |
Rights | open access | pt_BR |
Title | Creutzfeldt-Jakob disease and inclusion body myositis: abundant disease-associated prion protein in muscle. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1002/ana.10813 | |
Abstract | Pathological prion protein (PrPSc) is the hallmark ofprion diseases affecting primarily the central nervous sys-tem. Using immunohistochemistry, paraffin-embeddedtissue blot, and Western blot, we demonstrated abundant PrPScin the muscle of a patient with sporadicCreutzfeldt–Jakob disease and inclusion body myositis. Extraneural PrPC-PrPScconversion in Creutzfeldt–Jakobdisease appears to become prominent when PrPCis abun-dantly available as substrate, as in inclusion body myosi-tis muscle. | pt_BR |
Affilliation | University of Vienna. Institute of Neurology. Vienna, Austria / Austrian Reference Centre for Human Prion Diseases. Vienna, Austria / National Institute of Psychiatry and Neurology. Budapest, Hungary. | pt_BR |
Affilliation | University of Vienna. Institute of Neurology. Vienna, Austria / Austrian Reference Centre for Human Prion Diseases. Vienna, Austria. | pt_BR |
Affilliation | Federal University of Rio de Janeiro. School of Medicine. Department of Pathology. Rio de Janeiro, RJ, Brazil. | pt_BR |
Affilliation | Federal University of Rio de Janeiro. School of Medicine. Department of Neurology. Rio de Janeiro, RJ, Brazil. | pt_BR |
Affilliation | Federal University of São Paulo. School of Medicine. Department of Neurology. São Paulo, SP, Brazil. | pt_BR |
Affilliation | University of Vienna. Institute of Neurology. Vienna, Austria / Austrian Reference Centre for Human Prion Diseases. Vienna, Austria. | pt_BR |
Affilliation | University Hospital of Zürich. Institute of Neuropathology. Zürich, Switzerland. | pt_BR |
Affilliation | University Hospital of Zürich. Institute of Neuropathology. Zürich, Switzerland. | pt_BR |
Affilliation | University of Vienna. Institute of Neurology. Vienna, Austria / Austrian Reference Centre for Human Prion Diseases. Vienna, Austria. | pt_BR |
Subject | Creutzfeldt-Jakob disease | pt_BR |
Subject | Myositis | pt_BR |
Subject | Prion protein in muscle | pt_BR |
e-ISSN | 1531-8249 | |
Embargo date | 2020-05-03 | |