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Autor | Nascimento, Alessandro Rodrigues | |
Autor | Lessa, Marcos Adriano | |
Autor | Sabino, Bruno | |
Autor | Bousquet, Pascal | |
Autor | Tibiriçá, Eduardo | |
Fecha de acceso | 2019-05-23T16:55:43Z | |
Fecha de disponibilización | 2019-05-23T16:55:43Z | |
Fecha de publicación | 2010 | |
Referencia | NASCIMENTO, Alessandro Rodrigues et al. Microvascular Effects of Centrally Acting Antihypertensive Drugs in Spontaneously Hypertensive Rats. J. Cardiovasc. Pharmacol., v. 55, p. 240-247, 2010. | pt_BR |
ISSN | 0160-2446 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/33199 | |
Idioma | eng | pt_BR |
Editor | Lippincott, Williams & Wilkins | pt_BR |
Derechos de autor | restricted access | |
Palabras clave en Portugués | Rarefação Microvascular | pt_BR |
Palabras clave en Portugués | Clonidina | pt_BR |
Palabras clave en Portugués | Imidazolinas | pt_BR |
Palabras clave en Portugués | Capilaroscopia intravital | pt_BR |
Palabras clave en Portugués | Moxonidina | pt_BR |
Palabras clave en Portugués | Rilmenidina | pt_BR |
Palabras clave en Portugués | Rato espontaneamente hipertensivo | pt_BR |
Título | Microvascular Effects of Centrally Acting Antihypertensive Drugs in Spontaneously Hypertensive Rats | pt_BR |
Tipo del documento | Article | pt_BR |
DOI | 10.1097/FJC.0b013e3181ce9810 | pt_BR |
Resumen en Inglés | We investigated the effects of oral long-term antihypertensive treatment using centrally acting sympathoinhibitory drugs on capillary density in the skin, skeletal muscle, and heart in the spontaneously hypertensive rat (SHR). Wistar Kyoto rats (WKY) were used as normotensive control groups. Functional capillary density was assessed using intravital fluorescence videomicroscopy and structural capillary density with histochemical analysis. Groups of 10 SHRs were orally treated over 28 days with clonidine (0.1 mg kg21 d21), rilmenidine (1 mg kg21 d21), or moxonidine (10 mg kg21 d21). A group of WKY was also treated with clonidine (0.1 mg kg21 d21). Treatment with all antihypertensive drugs induced a normalization of arterial pressure accompanied by a reversion of functional capillary rarefaction in the skeletal muscle and skin of SHR. Clonidine treatment also reduced arterial pressure and increased functional capillary density in the skin and skeletal muscle of WKY. Histochemical analysis showed that SHR had a lower capillary to fiber ratio in the skeletal muscle (P , 0.0001), which was normalized by all treatments. The capillary volume density to fiber volume density ratio in the left ventricle of SHR was also significantly reduced (P , 0.0001). However, myocardial capillary rarefaction was not altered by the different treatments. In conclusion, the results showed that long-term antihypertensive treatment with centrally acting drugs enhanced tissue perfusion and reversed capillary rarefaction in the skeletal muscle of SHRs. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ. Brasil. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ. Brasil. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ. Brasil. | pt_BR |
Afiliación | Louis Pasteur University. Faculty of Medicine. Laboratory of Neurobiology and Cardiovascular Pharmacology. Strasbourg, France. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ. Brasil. | pt_BR |
Palavras clave en Inglês | Capillary rarefaction | pt_BR |
Palavras clave en Inglês | Intravital capillaroscopy | pt_BR |
Palavras clave en Inglês | Clonidine | pt_BR |
Palavras clave en Inglês | SHR | pt_BR |
Palavras clave en Inglês | Rilmenidine | pt_BR |
Palavras clave en Inglês | Moxonidine | pt_BR |
Palavras clave en Inglês | Imidazolines | pt_BR |
DeCS | Rarefação Microvascular | pt_BR |
DeCS | Imidazolinas | pt_BR |
e-ISSN | 1533-4023 | |
Fecha de embargo | 2022-01-01 |
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