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https://www.arca.fiocruz.br/handle/icict/33357
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ArtigoDireito Autoral
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- INI - Artigos de Periódicos [3392]
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CLINICAL FEATURES AND GENETIC BACKGROUND OF THE SYMPATRIC SPECIES PARACOCCIDIOIDES BRASILIENSIS AND PARACOCCIDIOIDES AMERICANA
Paracoccidioides brasiliensis
Paracoccidioides americana
Autor(es)
Afiliação
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ, Brasil.
University of Brasília. Faculty of Medicine. Brasília, DF, Brazil / Northern Arizona University. Pathogen and Microbiome Institute. Flagstaff, AZ, USA.
Northern Arizona University. Pathogen and Microbiome Institute. Flagstaff, AZ, USA.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ, Brasil.
University of Brasília. Faculty of Medicine. Brasília, DF, Brazil / Northern Arizona University. Pathogen and Microbiome Institute. Flagstaff, AZ, USA.
Northern Arizona University. Pathogen and Microbiome Institute. Flagstaff, AZ, USA.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ, Brasil.
Resumo em Inglês
Introduction: The agents of paracoccidioidomycosis, historically identified as Paracoccidioides brasiliensis, are in fact different phylogenetic species. This study aims to evaluate associations between Paracoccidioides phylogenetic species and corresponding clinical data. Methods: Paracoccidioides strains from INI/Fiocruz patients (1998–2016) were recovered. Sociodemographic, epidemiological, clinical, serological, therapeutic and prognostic data of the patients were collected to evaluate possible associations of these variables with the fungal species identified through partial sequencing of the ADP-ribosylation factor (arf) and the 43-
kDa-glycoprotein (gp43) genes. Results: Fifty-four fungal strains were recovered from 47 patients, most (72.3%) infected in Rio de Janeiro state, Brazil. Forty-one cases were caused by Paracoccidioides brasiliensis and six by Paracoccidioides americana (former PS2). P. brasiliensis was responsible for severe lymph abdominal forms, whereas patients infected with P. americana presented a high rate of adrenal involvement. However, no statistically significant associations were found for all variables studied. P. americana presented 100% reactivity to immunodiffusion, even when tested against antigens from other species, while negative results were observed in 9 (20%) cases caused by P. brasiliensis, despite being tested against a homologous antigen. Conclusions: P. brasiliensis and P. americana are sympatric and share similar clinical features and habitat, where they may compete for similar hosts.
Palavras-chave em inglês
ParacoccidioidomycosisParacoccidioides brasiliensis
Paracoccidioides americana
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