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NEUROLOGICAL MANIFESTATIONS IN HTLV-I INFECTED BLOOD DONORS
Blood donors
HTLV-I-associated myelopathy
Peripheral neuropath
Myopathy
Motor neuron disease
Autor
Afiliación
Fundação Oswaldo Cruz. Instituto de pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil / Rio de Janeiro’s State Institute of Hematology Arthur Siqueira Cavalcanti. Rio de Janeiro, RJ, Brazil.
Rio de Janeiro State University. Department of Epidemiology. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
The Fluminense Federal University. Service of Neurology. Niterói, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Rio de Janeiro State University. Department of Epidemiology. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
The Fluminense Federal University. Service of Neurology. Niterói, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Resumen en ingles
The human T-cell lymphotropic virus type 1 (HTLV-I) causes a neurological disease known as HTLV-I-associated myelopathy/tropicalspastic paraparesis (HAM/TSP) in a minority of infected individuals. Although other neurological outcomes have been described theirprevalence is presently unknown. To evaluate the frequency and characteristics of neurological involvement in a population of HTLV-I-infected blood donors we investigated 196 HTLV-I positive and 196 negative blood donors from a blood center of Rio de Janeiro, Brazil.Individuals with abnormalities at the neurological examination were examined by three neurologists, and when pertinent, additionalneurological investigations were performed. Descriptive analysis, Student’st-test andv2test were employed for statistical analysis.Neurological abnormalities were found in 71 (36.2%) of the HTLV-I positive blood donors and in only 29 (14.8%) of the HTLV-I negativedonors (OR = 2.54, 95% CI = 1.67–3.59,p=0.000002). Cases of myelopathy, motor neuron disease and myopathy were only found in theHTLV-I positive group. In addition, peripheral neuropathy (PN) was significantly more frequent in the positive group (p= 0.015). Insummary, our data suggest that HTLV-I-infected individuals exhibit a wide variety of neurological manifestations apart from the classicalpicture of HAM/TSP.
Palabras clave en ingles
HTLV-IBlood donors
HTLV-I-associated myelopathy
Peripheral neuropath
Myopathy
Motor neuron disease
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