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Autor | Leite, Ana C. C. | pt_BR |
Autor | Mendonça, Gulnar A. S. | pt_BR |
Autor | Serpa, Maria José Andrada | pt_BR |
Autor | Nascimento, Osvaldo J. M. | pt_BR |
Autor | Araújo, Abelardo Q.-C. | pt_BR |
Fecha de acceso | 2019-06-11T13:02:32Z | |
Fecha de disponibilización | 2019-06-11T13:02:32Z | |
Fecha de publicación | 2003 | |
Referencia | LEITE, Ana C.C et al. Neurological manifestations in HTLV-I infected blood donors. Journal of the Neurological Science, v. 214, n. 1-2, p. 49-56, 2003. | pt_BR |
ISSN | 0022-510X | |
URI | https://www.arca.fiocruz.br/handle/icict/33453 | |
Idioma | por | pt_BR |
Derechos de autor | restricted access | pt_BR |
Título | Neurological manifestations in HTLV-I infected blood donors | pt_BR |
Tipo del documento | Article | pt_BR |
DOI | 10.1016/S0022-510X(03)00179-5 | pt_BR |
Resumen en Inglés | The human T-cell lymphotropic virus type 1 (HTLV-I) causes a neurological disease known as HTLV-I-associated myelopathy/tropicalspastic paraparesis (HAM/TSP) in a minority of infected individuals. Although other neurological outcomes have been described theirprevalence is presently unknown. To evaluate the frequency and characteristics of neurological involvement in a population of HTLV-I-infected blood donors we investigated 196 HTLV-I positive and 196 negative blood donors from a blood center of Rio de Janeiro, Brazil.Individuals with abnormalities at the neurological examination were examined by three neurologists, and when pertinent, additionalneurological investigations were performed. Descriptive analysis, Student’st-test andv2test were employed for statistical analysis.Neurological abnormalities were found in 71 (36.2%) of the HTLV-I positive blood donors and in only 29 (14.8%) of the HTLV-I negativedonors (OR = 2.54, 95% CI = 1.67–3.59,p=0.000002). Cases of myelopathy, motor neuron disease and myopathy were only found in theHTLV-I positive group. In addition, peripheral neuropathy (PN) was significantly more frequent in the positive group (p= 0.015). Insummary, our data suggest that HTLV-I-infected individuals exhibit a wide variety of neurological manifestations apart from the classicalpicture of HAM/TSP. | |
Afiliación | Fundação Oswaldo Cruz. Instituto de pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil / Rio de Janeiro’s State Institute of Hematology Arthur Siqueira Cavalcanti. Rio de Janeiro, RJ, Brazil. | |
Afiliación | Rio de Janeiro State University. Department of Epidemiology. Rio de Janeiro, RJ, Brasil. | |
Afiliación | Fundação Oswaldo Cruz. Instituto de pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | |
Afiliación | The Fluminense Federal University. Service of Neurology. Niterói, RJ, Brasil. | |
Afiliación | Fundação Oswaldo Cruz. Instituto de pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | |
Palavras clave en Inglês | HTLV-I | |
Palavras clave en Inglês | Blood donors | |
Palavras clave en Inglês | HTLV-I-associated myelopathy | |
Palavras clave en Inglês | Peripheral neuropath | |
Palavras clave en Inglês | Myopathy | |
Palavras clave en Inglês | Motor neuron disease |
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