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https://www.arca.fiocruz.br/handle/icict/33569
DORATOXYLON APETALUM, AN INDIGENOUS MEDICINAL PLANT FROM MASCARENE ISLANDS, IS A POTENT INHIBITOR OF ZIKA AND DENGUE VIRUS INFECTION IN HUMAN CELLS
Dengue Virus
Antiviral Agents
Plants
Dietary Supplements
Polyphenols
Virus del Dengue
Antivirales
Plantas Medicinales
Suplementos Dietéticos
Polifenoles
Autor(es)
Afiliação
Université de la Réunion. Unité Mixte Processus Infectieux en Milieu Insulaire Tropical. Plateforme Technologique CYROI. La Réunion, France.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.
Bioactive Natural Products Unit. School of Pharmaceutical Sciences. University of Geneva. Geneva, Switzerland.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.
Université de la Réunion. Unité Mixte Processus Infectieux en Milieu Insulaire Tropical. Plateforme Technologique CYROI. La Réunion, France.
Université de la Réunion. Unité Mixte Processus Infectieux en Milieu Insulaire Tropical. Plateforme Technologique CYROI. La Réunion, France.
Université de la Réunion. Unité Mixte Processus Infectieux en Milieu Insulaire Tropical. Plateforme Technologique CYROI. La Réunion, France.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.
Bioactive Natural Products Unit. School of Pharmaceutical Sciences. University of Geneva. Geneva, Switzerland.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.
Université de la Réunion. Unité Mixte Processus Infectieux en Milieu Insulaire Tropical. Plateforme Technologique CYROI. La Réunion, France.
Université de la Réunion. Unité Mixte Processus Infectieux en Milieu Insulaire Tropical. Plateforme Technologique CYROI. La Réunion, France.
Université de la Réunion. Unité Mixte Processus Infectieux en Milieu Insulaire Tropical. Plateforme Technologique CYROI. La Réunion, France.
Resumo em Inglês
Zika virus (ZIKV) and Dengue virus (DENV) are mosquito-borne viruses of the Flavivirus genus that could cause congenital microcephaly and hemorrhage, respectively, in humans, and thus present a risk to global public health. A preventive vaccine against ZIKV remains unavailable, and no specific antiviral drugs against ZIKV and DENV are licensed. Medicinal plants may be a source of natural antiviral drugs which mostly target viral entry. In this study, we evaluate the antiviral activity of Doratoxylum apetalum, an indigenous medicinal plant from the Mascarene Islands, against ZIKV and DENV infection. Our data indicated that D. apetalum exhibited potent antiviral activity against a contemporary epidemic strain of ZIKV and clinical isolates of four DENV serotypes at non-cytotoxic concentrations in human cells. Time-of-drug-addition assays revealed that D. apetalum extract acts on ZIKV entry by preventing the internalisation of virus particles into the host cells. Our data suggest that D. apetalum-mediated ZIKV inhibition relates to virus particle inactivation. We suggest that D. apetalum could be a promising natural source for the development of potential antivirals against medically important flaviviruses.
Palavras-chave
Doratoxylon apetalumPalavras-chave em inglês
Zika VirusDengue Virus
Antiviral Agents
Plants
Dietary Supplements
Polyphenols
Palavras-chave em espanhol
Virus ZikaVirus del Dengue
Antivirales
Plantas Medicinales
Suplementos Dietéticos
Polifenoles
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