Author | Haddad, Juliano G. | |
Author | Koishi, Andrea Cristine | |
Author | Gaudry, Arnaud | |
Author | Santos, Claudia Nunes Duarte dos | |
Author | Viranaicken, Wildriss | |
Author | Desprès, Philippe | |
Author | El Kalamouni, Chaker | |
Access date | 2019-06-18T18:35:11Z | |
Available date | 2019-06-18T18:35:11Z | |
Document date | 2019 | |
Citation | HADDAD, Juliano G. et al. Doratoxylon apetalum, an indigenous medicinal plant from Mascarene Islands, is a potent inhibitor of Zika and Dengue Virus infection in human cells. International Journal of Molecular Sciences, v. 20, n. 2382, p. 1-13, 2019. | pt_BR |
ISSN | 1661-6596 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/33569 | |
Language | por | pt_BR |
Publisher | MDPI | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Doratoxylon apetalum | pt_BR |
Title | Doratoxylon apetalum, an indigenous medicinal plant from Mascarene Islands, is a potent inhibitor of Zika and Dengue Virus infection in human cells | pt_BR |
Type | Article | pt_BR |
DOI | 10.3390/ijms20102382 | |
Abstract | Zika virus (ZIKV) and Dengue virus (DENV) are mosquito-borne viruses of the Flavivirus genus that could cause congenital microcephaly and hemorrhage, respectively, in humans, and thus present a risk to global public health. A preventive vaccine against ZIKV remains unavailable, and no specific antiviral drugs against ZIKV and DENV are licensed. Medicinal plants may be a source of natural antiviral drugs which mostly target viral entry. In this study, we evaluate the antiviral activity of Doratoxylum apetalum, an indigenous medicinal plant from the Mascarene Islands, against ZIKV and DENV infection. Our data indicated that D. apetalum exhibited potent antiviral activity against a contemporary epidemic strain of ZIKV and clinical isolates of four DENV serotypes at non-cytotoxic concentrations in human cells. Time-of-drug-addition assays revealed that D. apetalum extract acts on ZIKV entry by preventing the internalisation of virus particles into the host cells. Our data suggest that D. apetalum-mediated ZIKV inhibition relates to virus particle inactivation. We suggest that D. apetalum could be a promising natural source for the development of potential antivirals against medically important flaviviruses. | pt_BR |
Affilliation | Université de la Réunion. Unité Mixte Processus Infectieux en Milieu Insulaire Tropical. Plateforme Technologique CYROI. La Réunion, France. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Bioactive Natural Products Unit. School of Pharmaceutical Sciences. University of Geneva. Geneva, Switzerland. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Université de la Réunion. Unité Mixte Processus Infectieux en Milieu Insulaire Tropical. Plateforme Technologique CYROI. La Réunion, France. | pt_BR |
Affilliation | Université de la Réunion. Unité Mixte Processus Infectieux en Milieu Insulaire Tropical. Plateforme Technologique CYROI. La Réunion, France. | pt_BR |
Affilliation | Université de la Réunion. Unité Mixte Processus Infectieux en Milieu Insulaire Tropical. Plateforme Technologique CYROI. La Réunion, France. | pt_BR |
Subject | Zika Virus | pt_BR |
Subject | Dengue Virus | pt_BR |
Subject | Antiviral Agents | pt_BR |
Subject | Plants | pt_BR |
Subject | Dietary Supplements | pt_BR |
Subject | Polyphenols | pt_BR |
Subject in Spanish | Virus Zika | pt_BR |
Subject in Spanish | Virus del Dengue | pt_BR |
Subject in Spanish | Antivirales | pt_BR |
Subject in Spanish | Plantas Medicinales | pt_BR |
Subject in Spanish | Suplementos Dietéticos | pt_BR |
Subject in Spanish | Polifenoles | pt_BR |
DeCS | Zika virus | pt_BR |
DeCS | Vírus da Dengue | pt_BR |
DeCS | Antivirais | pt_BR |
DeCS | Plantas Medicinais | pt_BR |
DeCS | Suplementos Nutricionais | pt_BR |
DeCS | Polifenóis | pt_BR |