Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/33598
Type
ArticleCopyright
Restricted access
Embargo date
2022-01-01
Collections
Metadata
Show full item record
MESOPOROUS SILICA NANOCARRIERS ENCAPSULATED ANTIMALARIALS WITH HIGH THERAPEUTIC PERFORMANCE
Author
Affilliation
Federal University of Agriculture. College of Physical Sciences. Department of Chemistry. Abeokuta, Abeokuta, Nigeria/ Kumamoto University. Graduate School of Science and Technology. Department of Chemistry. Kurokami, Chuo-ku, Kumamoto, Japan
Kumamoto University. Graduate School of Science and Technology. Department of Chemistry. Kurokami, Chuo-ku, Kumamoto, Japan
University of Ilorin. Faculty of Physical Sciences. Department of Chemistry. Ilorin, Kwara State, Nigeria
University of Ibadan. College of Medicine University College Hospital. Institute for Advanced Medical Research and Training. Ibadan, Nigeria
University of Ilorin. Faculty of Physical Sciences. Department of Chemistry. Ilorin, Kwara State, Nigeria
University of Ilorin. Faculty of Physical Sciences. Department of Chemistry. Ilorin, Kwara State, Nigeria
Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratorio de Malaria. Belo Horizonte, MG, Brazil
The University of Queensland. Australian Institute for Bioengineering and Nanotechnology. Queensland, QLD, Australia
Kumamoto University. Graduate School of Science and Technology. Department of Chemistry. Kurokami, Chuo-ku, Kumamoto, Japan/ Kumamoto University. Institute of Pulsed Power Science. Kurokami, Chuo-ku, Kumamoto, Japan
Kumamoto University. Graduate School of Science and Technology. Department of Chemistry. Kurokami, Chuo-ku, Kumamoto, Japan
University of Ilorin. Faculty of Physical Sciences. Department of Chemistry. Ilorin, Kwara State, Nigeria
University of Ibadan. College of Medicine University College Hospital. Institute for Advanced Medical Research and Training. Ibadan, Nigeria
University of Ilorin. Faculty of Physical Sciences. Department of Chemistry. Ilorin, Kwara State, Nigeria
University of Ilorin. Faculty of Physical Sciences. Department of Chemistry. Ilorin, Kwara State, Nigeria
Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratorio de Malaria. Belo Horizonte, MG, Brazil
The University of Queensland. Australian Institute for Bioengineering and Nanotechnology. Queensland, QLD, Australia
Kumamoto University. Graduate School of Science and Technology. Department of Chemistry. Kurokami, Chuo-ku, Kumamoto, Japan/ Kumamoto University. Institute of Pulsed Power Science. Kurokami, Chuo-ku, Kumamoto, Japan
Abstract
The use of nanocarriers in drug delivery is a breakeven research and has received a clarion call in biomedicine globally. Herein, two newly nano-biomaterials: MCM-41 encapsulated quinine (MCM-41 ⊃ QN) (1) and 3-phenylpropyl silane functionalized MCM-41 loaded QN (pMCM-41 ⊃ QN) (2) were synthesized and well characterized. 1 and 2 along with our two already reported nano-antimalarial drugs (MCM-41 ⊃ ATS) (3) and 3-aminopropyl silane functionalized MCM-41 contained ATS (aMCM-41 ⊃ ATS) (4) were screened in vitro for their activity against P. falciparium W2 strain, cytotoxicity against BGM cells and in vivo for their activity against Plasmodium bergheiNK65. 1 has the highest antimalarial activity in vivo against P. berghei NK65, (ED50: < 0.0625 mg/kg body weight) and higher mean survival time compared to the other nano biomaterials or unencapsulated drugs at doses higher than 0.0625 mg/kg body weight. This encapsulation strategy of MCM-41 ⊃ QN (1) stands very useful and effective in delivering the drug to the target cells compared to other delivery systems and therefore, this encapsulated drug may be considered for rational drug design.
Share