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Autor | Machado, Marılia Carneiro | |
Autor | Costa Neto, João Moreira da | |
Autor | Portela, Ricardo Dias | |
Autor | D’Assis, Mario Jorge Melhor Heine | |
Autor | Martins Filho, Olindo Assis | |
Autor | Melo, Stella Maria Barrouin | |
Autor | Borges, Natalie Ferreira | |
Autor | Silva, Fabiana Lessa | |
Autor | Lima, Alessandra Estrela | |
Fecha de acceso | 2019-07-02T14:26:30Z | |
Fecha de disponibilización | 2019-07-02T14:26:30Z | |
Fecha de publicación | 2018 | |
Referencia | MACHADO, Marılia Carneiro et al. The effect of naltrexone as a carboplatin chemotherapy-associated drug on the immune response, quality of life and survival of dogs with mammary carcinoma. PLoS One, v. 13, n. 10, p. 1-16, 2018. | pt_BR |
ISSN | 1932-6203 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/33775 | |
Idioma | eng | pt_BR |
Editor | Public Library of Science | pt_BR |
Derechos de autor | open access | pt_BR |
Palabras clave en Portugués | Cancer da mama | pt_BR |
Título | The effect of naltrexone as a carboplatin chemotherapy-associated drug on the immune response, quality of life and survival of dogs with mammary carcinoma | pt_BR |
Tipo del documento | Article | pt_BR |
DOI | 10.1371/journal.pone.0204830 | |
Resumen en Inglés | The objective of this study was to evaluate the effect of low-dose naltrexone (LDN) as a carboplatin chemotherapy-associated drug in female dogs with mammary carcinoma in benign mixed tumors (MC-BMT) after mastectomy and to assess its association with quality of life and survival rates. Sixty female dogs were included in this study, all of which had histopathological diagnosis of MC-BMT and were divided into three groups: G1 (control), consisting of animals submitted only to mastectomy with or without regional metastasis; G2, composed of treated animals that did not present with metastasis; and G3, treated dogs that presented with metastasis. G2 and G3 were also subdivided according to the treatment administered: chemotherapy alone (MC-BMT(-) C/MC-BMT(+) C) or LDN and chemotherapy (MC-BMT(-) C+LDN/MC-BMT(+) C+LDN). All animals were subjected to clinical evaluation, mastectomy, peripheral blood lymphocyte immunophenotyping, beta-endorphin and met-enkephalin quantification, and evaluation of survival rates and quality of life scores. The results showed higher serum concentrations of beta-endorphin and met-enkephalin, fewer chemotherapy-related side effects, and better quality of life and survival rates in the LDN-treated groups than in LDN-untreated groups (P < 0.05). Evaluation of clinical and pathological parameters indicated a significant association between the use of LDN and both prolonged survival and enhanced quality of life. These results indicate that LDN is a viable chemotherapy-associated treatment in female dogs with MC-BMT, maintaining their quality of life and prolonging survival rates. | pt_BR |
Afiliación | Universidade Federal da Bahia.Departamento de Anatomia, Patologia e Clínicas Veterinárias. Salvador, BA, Brasil. | pt_BR |
Afiliación | Universidade Federal da Bahia.Departamento de Anatomia, Patologia e Clínicas Veterinárias. Salvador, BA, Brasil. | pt_BR |
Afiliación | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Imunologia e Biologia Molecular. Salvador, BA, Brasil. | pt_BR |
Afiliación | Universidade Federal da Bahia. Departamento de Anatomia, Patologia e Clínicas Veterinárias. Salvador, BA, Brasil. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoramento.Belo Horizonte, MG, Brasil. | pt_BR |
Afiliación | Universidade Federal da Bahia. Departamento de Anatomia, Patologia e Clínicas Veterinárias. Salvador, BA, Brasil. | pt_BR |
Afiliación | Centro de Ciências Agrárias, Ambientais e Biológicas. Universidade Federal de Reconcavo da Bahia. Cruz das Almas, BA, Brasil. | pt_BR |
Afiliación | Departamento de Ciências Agrárias e Ambientais. Universidade Estadual de Santa Cruz. Ilhéus, BA, Brasil. | pt_BR |
Afiliación | Universidade Federal da Bahia. Departamento de Anatomia, Patologia e Clínicas Veterinárias. Salvador, BA, Brasil. | pt_BR |
Palavras clave en Inglês | Mammary carcinoma | pt_BR |