Author | Siciliano, Rinaldo Focaccia | |
Author | Gualandro, Danielle Menosi | |
Author | Sejas, Odeli Nicole Encinas | |
Author | Ignoto, Bruno Giuliano | |
Author | Caramelli, Bruno | |
Author | Mansur, Alfredo Jose | |
Author | Sampaio, Roney Orismar | |
Author | Pierrotti, Ligia Camera | |
Author | Barbosa, Giovanna | |
Author | Golebiovski, Wilma | |
Author | Weksler, Clara | |
Author | Lamas, Cristiane | |
Author | Fortes, Natália Rodrigues Querido | |
Author | Fortes, Claudio Querido | |
Author | Tarasoutchi, Flavio | |
Author | Strabelli, Tania Mara Varejão | |
Access date | 2019-07-08T15:01:19Z | |
Available date | 2019-07-08T15:01:19Z | |
Document date | 2018 | |
Citation | SICILIANO, Rinaldo Focaccia et al. Outcomes in patients with fungal endocarditis: a multicenter observational cohort study. International Journal of Infectious Diseases, v. 77, p. 48-52, Dec. 2018. | pt_BR |
ISSN | 1201-9712 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/33880 | |
Description | Cristiane Lamas. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. | pt_BR |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Title | Outcomes in patients with fungal endocarditis: A multicenter observational cohort study | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.ijid.2018.09.016 | |
Abstract | Objective: To compare the clinical and epidemiological features, treatments, and outcomes of patients with isolated right-sided and left-sided fungal endocarditis and to determine the risk factors for in-hospital mortality in patients with Candida sp endocarditis. Methods: A retrospective review of all consecutive cases of fungal endocarditis from five hospitals was performed. Clinical features were compared between patients with isolated right-sided and left-sided endocarditis. In the subgroup of fungal endocarditis due to Candida species, binary logistic regression analysis was performed to determine variables related to in-hospital mortality. Results: Seventy-eight patients with fungal endocarditis were studied. Their median age was 50 years; 55% were male and 19 patients (24%) had isolated right-sided endocarditis. Overall, cardiac surgery was performed in 46 patients (59%), and in-hospital mortality was 54%. Compared to patients with left-side fungal endocarditis, patients with isolated right-sided endocarditis had lower mortality (32% vs. 61%; p = 0.025) and were less often submitted to cardiac surgery (37% vs. 66%; p = 0.024). The most frequent etiology was Candida spp (85%). In this subgroup, acute heart failure (odds ratio 5.0; p = 0.027) and exclusive medical treatment (odds ratio 11.1; p = 0.004) were independent predictors of in-hospital death, whereas isolated right-sided endocarditis was related to a lower risk of mortality (odds ratio 0.13; p = 0.023). Conclusions: Patients with isolated right-sided fungal endocarditis have particular clinical and epidemiological features. They were submitted to cardiac surgery less often and had better survival than patients with left-sided fungal endocarditis. Isolated right-sided endocarditis was also a marker of a less harmful illness in the subgroup of Candida sp endocarditis. | pt_BR |
Affilliation | University of São Paulo. Medical School. Heart Institute. Infection Control Team. São Paulo, SP, Brazil. | pt_BR |
Affilliation | University of São Paulo. Medical School. Heart Institute. Cardiology Department. São Paulo, SP, Brazil. | pt_BR |
Affilliation | University of São Paulo. Medical School. Heart Institute. Infection Control Team. São Paulo, SP, Brazil. | pt_BR |
Affilliation | University of São Paulo. Medical School. Heart Institute. Infection Control Team. São Paulo, SP, Brazil. | pt_BR |
Affilliation | University of São Paulo. Medical School. Heart Institute. Cardiology Department. São Paulo, SP, Brazil. | pt_BR |
Affilliation | University of São Paulo. Medical School. Heart Institute. Cardiology Department. São Paulo, SP, Brazil. | pt_BR |
Affilliation | University of São Paulo. Medical School. Heart Institute. Cardiology Department. São Paulo, SP, Brazil. | pt_BR |
Affilliation | Instituto do Câncer do Estado de São Paulo. Infection Control Team. São Paulo, SP, Brazil. | pt_BR |
Affilliation | Instituto Nacional de Cardiologia do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto Nacional de Cardiologia do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto Nacional de Cardiologia do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto Nacional de Cardiologia do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | University of São Paulo. Medical School. Heart Institute. Cardiology Department. São Paulo, SP, Brazil. | pt_BR |
Affilliation | University of São Paulo. Medical School. Heart Institute. Infection Control Team. São Paulo, SP, Brazil. | pt_BR |
Subject | Endocarditis | pt_BR |
Subject | Fungi | pt_BR |
Subject | Candida | pt_BR |
e-ISSN | 1878-3511 | |