Author | Lima, Rafaely Nascimento | |
Author | Ribeiro, Adauto S. | |
Author | Santiago, Gilvandete MariaPinheiro | |
Author | Costa, Cinara Oliveira d´Souza | |
Author | Soares, Milena Botelho Pereira | |
Author | Bezerra, Daniel Pereira | |
Author | Shanmugam, Saravanan | |
Author | Freitas, Lisiane dos S. | |
Author | Alves, Pericles Barreto | |
Access date | 2019-08-12T13:11:50Z | |
Available date | 2019-08-12T13:11:50Z | |
Document date | 2019 | |
Citation | LIMA, Rafaely Nascimento et al. Antitumor and Aedes aegypti Larvicidal Activities of Essential Oils From Piper klotzschianum, P. hispidum, and P. arboreum. Natural Product Communications, p. 1-6, July 2019. | pt_BR |
ISSN | 1934-578X | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/34722 | |
Sponsorship | CAPES (Coordenação de Aperfeiçoamento de
Pessoal de Nível Superior), project PROMOB-Fapitec/CApES) and
UFS. | pt_BR |
Language | eng | pt_BR |
Publisher | SAGE Publications | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Piper | pt_BR |
Subject in Portuguese | Aedes aegypti | pt_BR |
Subject in Portuguese | Citotoxicidade | pt_BR |
Subject in Portuguese | Óleo essencial | pt_BR |
Subject in Portuguese | Larvicida | pt_BR |
Title | Antitumor and Aedes aegypti Larvicidal Activities of Essential Oils From Piper klotzschianum, P. hispidum, and P. arboreum | pt_BR |
Type | Article | pt_BR |
DOI | 10.1177/1934578X19863932 | pt_BR |
Abstract | The chemical constituents of essential oils extracted by hydrodistillation from Piper klotzschianum, P. hispidum, and P. arboreum, collected from the remaining Atlantic forest in Sergipe State, were characterized and submitted to cytotoxic and larvicidal activity assays. The major constituents identified (stems, fresh, and dried leaves) were (E)-caryophyllene (16.8%) and bicyclogermacrene (21.6%). Germacrene D (22.8%) was identified only in P. klotzschianum and P. hispidum. A high percentage of β-pinene (27.2%) and
α-pinene (7.2%) were present in P. klotzschianum stems and δ-3-carene in the fresh and dried leaves of P. hispidum (17.4% and 19.1%, respectively). Piper klotzschianum showed the best cytotoxic activity, inhibiting human hepatocellular carcinoma (27.3 μg/mL), human promyelocytic leukemia (33.8 μg/mL), and murine melanoma (37.9 μg/mL) cell lines. Larvicidal activity was also tested and the essential oil from the dried leaves of P. klotzschianum was the most potent against Aedes aegypti larvae, with an LC50 value of 122.4 μg/mL. | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Química. São Cristovão, SE, Brasil. | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Química. São Cristovão, SE, Brasil. | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Biologia. São Cristovão, SE, Brasil / Universidade Federal do Ceará. Departamento de Farmácia. Fortaleza, CE, Brasil. | pt_BR |
Affilliation | Universidade Federal do Ceará. Departamento de Farmácia. Fortaleza, CE, Brasil. | pt_BR |
Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil /Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil /Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil /Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Química. São Cristovão, SE, Brasil / Universidade Federal de Sergipe. Departamento de Farmácia. São Cristóvão, SE, Brasil. | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Química. São Cristovão, SE, Brasil. | pt_BR |
Subject | Piper | pt_BR |
Subject | Aedes aegypti | pt_BR |
Subject | Cytotoxicity | pt_BR |
Subject | Essential oil | pt_BR |
Subject | Larvicidal | pt_BR |