Author | Lin, Chunqing | |
Author | Slama, Jiri | |
Author | Gonzalez, Paula | |
Author | Goodman, Marc T. | |
Author | Xia, Ningshao | |
Author | Kreimer, Aimée R. | |
Author | Wu, Ting | |
Author | Hessol, Nancy A. | |
Author | Shvetsov, Yurii | |
Author | Ortiz, Ana P. | |
Author | Grinsztejn, Beatriz | |
Author | Moscicki, Anna-Barbara | |
Author | Heard, Isabelle | |
Author | Del Refugio González Losa, María | |
Author | Kojic, Erna M. | |
Author | Schim van der Loeff, Maarten F. | |
Author | Wei, Feixue | |
Author | Longatto-Filho, Adhemar | |
Author | Mbulawa, Zizipho A. | |
Author | Palefsky, Joel M. | |
Author | Sohn, Annette H. | |
Author | Hernandez, Brenda Y. | |
Author | Robison, Katina | |
Author | Simpson, Steve | |
Author | Conley, Lois J. | |
Author | de Pokomandy, Alexandra | |
Author | van der Sande, Marianne A. B. | |
Author | Dube Mandishora, Racheal S. | |
Author | Volpini, Lays P. B. | |
Author | Pierangeli, Alessandra | |
Author | Romero, Byron | |
Author | Wilkin, Timothy | |
Author | Franceschi, Silvia | |
Author | Hidalgo-Tenorio, Carmen | |
Author | Ramautarsing, Reshmie A. | |
Author | Park, Ina U. | |
Author | Tso, Fernanda K. | |
Author | Godbole, Sheela | |
Author | D'Hauwers, Kathleen W. M. | |
Author | Sehnal, Borek | |
Author | Menezes, Lynette J. | |
Author | Heráclio, Sandra A. | |
Author | Clifford, Gary M. | |
Access date | 2019-08-14T15:09:59Z | |
Available date | 2019-08-14T15:09:59Z | |
Document date | 2019 | |
Citation | LIN, Chunqing et al. Cervical determinants of anal HPV infection and high-grade anal lesions in women: a collaborative pooled analysis. The Lancet Infectious Diseases, v. 19, n. 8, p. 880-891, 2019. | pt_BR |
ISSN | 1473-3099 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/34804 | |
Sponsorship | International Agency for Research on Cancer | pt_BR |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Title | Cervical determinants of anal HPV infection and high-grade anal lesions in women: a collaborative pooled analysis | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/S1473-3099(19)30164-1 | |
Abstract | Background: Cervical cancer screening might contribute to the prevention of anal cancer in women. We aimed to investigate if routine cervical cancer screening results-namely high-risk human papillomavirus (HPV) infection and cytohistopathology-predict anal HPV16 infection, anal high-grade squamous intraepithelial lesions (HSIL) and, hence, anal cancer. Methods: We did a systematic review of MEDLINE, Embase, and the Cochrane library for studies of cervical determinants of anal HPV and HSIL published up to Aug 31, 2018. We centrally reanalysed individual-level data from 13 427 women with paired cervical and anal samples from 36 studies. We compared anal high-risk HPV prevalence by HIV status, cervical high-risk HPV, cervical cytohistopathology, age, and their combinations, using prevalence ratios (PR) and 95% CIs. Among 3255 women with anal cytohistopathology results, PRs were similarly calculated for all anal HSIL and HPV16-positive anal HSIL. Findings: Cervical and anal HPV infections were highly correlated. In HIV-negative women, anal HPV16 prevalence was 41% (447/1097) in cervical HPV16-positive versus 2% (214/8663) in cervical HPV16-negative women (PR 16·5, 95% CI 14·2-19·2, p<0·0001); these values were 46% (125/273) versus 11% (272/2588) in HIV-positive women (4·4, 3·7-5·3, p<0·0001). Anal HPV16 was also associated with cervical cytohistopathology, with a prevalence of 44% [101/228] for cervical cancer in HIV-negative women (PR vs normal cytology 14·1, 11·1-17·9, p<0·0001). Anal HSIL was associated with cervical high-risk HPV, both in HIV-negative women (from 2% [11/527] in cervical high-risk HPV-negative women up to 24% [33/138] in cervical HPV16-positive women; PR 12·9, 95% CI 6·7-24·8, p<0·0001) and HIV-positive women (from 8% [84/1094] to 17% [31/186]; 2·3, 1·6-3·4, p<0·0001). Anal HSIL was also associated with cervical cytohistopathology, both in HIV-negative women (from 1% [5/498] in normal cytology up to 22% [59/273] in cervical HSIL; PR 23·1, 9·4-57·0, p<0·0001) and HIV-positive women (from 7% [105/1421] to 25% [25/101]; 3·6, 2·5-5·3, p<0·0001). Prevalence of HPV16-positive anal HSIL was 23-25% in cervical HPV16-positive women older than 45 years (5/20 in HIV-negative women, 12/52 in HIV-positive women).
Interpretation: HPV-based cervical cancer screening programmes might help to stratify anal cancer risk, irrespective of HIV status. For targeted secondary anal cancer prevention in high-risk groups, HIV-negative women with cervical HPV16, especially those older than 45 years, have a similar anal cancer risk profile to that of HIV-positive women. | pt_BR |
Affilliation | International Agency for Research on Cancer, Lyon, France; National Cancer Center, National Clinical Research Center for Cancer, and Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. | pt_BR |
Affilliation | Department of Gynecology and Obstetrics, General University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic. | pt_BR |
Affilliation | Proyecto Epidemiológico Guanacaste, Fundación INCIENSA, San José, Costa Rica. | pt_BR |
Affilliation | Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA. | pt_BR |
Affilliation | State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, China. | pt_BR |
Affilliation | National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. | pt_BR |
Affilliation | State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, China. | pt_BR |
Affilliation | University of California, San Francisco, CA, USA. | pt_BR |
Affilliation | University of Hawaii Cancer Center, Honolulu, Hawaii, USA. | pt_BR |
Affilliation | University of Puerto Rico Comprehensive Cancer Center, Department of Biostatistics and Epidemiology, Graduate School of Public Health, UPR, San Juan, Puerto Rico. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS.Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | David Geffen School of Medicine, University of California, Los Angeles, CA, USA. | pt_BR |
Affilliation | Department of Endocrinology and Reproductive Medicine, IE3M, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique, Hôpitaux de Paris, Paris, France. | pt_BR |
Affilliation | Dr Hideyo Noguchy Center of Regional Investigations, Autonomous University of Yucatán, Mérida, Yucatán, México. | pt_BR |
Affilliation | Mount Sinai West and St Luke's Hospitals, New York, NY, USA. | pt_BR |
Affilliation | Department of Infectious Diseases, Infectious Diseases Research & Prevention, GGD Amsterdam, Netherlands. | pt_BR |
Affilliation | State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, China. | pt_BR |
Affilliation | Research Institute of Life and Health Sciences, School of Medicine, University of Minho, Braga, Portugal; 3B's (Biomaterials, Biodegradables and Biomimetics) Research Group, Portugal Government Associate Laboratory, Braga, Portugal; Laboratory of Medical Investigation 14, Department of Pathology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil; Teaching and Research Institute, Molecular Oncology Research Center, Barretos Cancer Hospital-Pio XII Foundation, Barretos, Brazil. | pt_BR |
Affilliation | Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Department of Pathology, Division of Medical Virology, University of Cape Town, Cape Town, South Africa; Centre for HIV and STIs, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa; South African Medical Research Council Gynaecological Cancer Research Centre, University of Cape Town, Cape Town, South Africa. | pt_BR |
Affilliation | University of California, San Francisco, CA, USA. | pt_BR |
Affilliation | TREAT Asia/amfAR-Foundation for AIDS Research, Thai Red Cross AIDS Research Centre, Bangkok, Thailand. | pt_BR |
Affilliation | Obstetrics & Gynecology and Medicine, The Warren Alpert Medical School of Brown University, Providence, RI, USA. | pt_BR |
Affilliation | Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia. | pt_BR |
Affilliation | Division of HIV/AIDS Prevention, Epidemiology Research Team, Centers for Disease Control and Prevention, Atlanta, GA, USA. | pt_BR |
Affilliation | Chronic Viral Illness Service, McGill University Health Centre and Department of Family Medicine, McGill University, Montreal, QC, Canada. | pt_BR |
Affilliation | Public Health Epidemiology, Head Department Public Health, Institute of Tropical Medicine, Antwerp, Belgium. | pt_BR |
Affilliation | Department of Medical Microbiology, University of Zimbabwe College of Health Sciences, Parirenyatwa Hospital premises, Harare, Zimbabwe. | pt_BR |
Affilliation | Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Espírito Santo, Vitória, Brasil. | pt_BR |
Affilliation | Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy. | pt_BR |
Affilliation | Weill Cornell Medicine, New York, NY, USA. | pt_BR |
Affilliation | Aviano Cancer Center, Aviano, Italy. | pt_BR |
Affilliation | Infectious Diseases Service, University Hospital Virgen de las Nieves, Granada, Spain. | pt_BR |
Affilliation | Thai Red Cross AIDS Research Centre, Bangkok, Thailand. | pt_BR |
Affilliation | Department of Family and Community Medicine, University of California San Francisco School of Medicine, San Francisco, CA, USA. | pt_BR |
Affilliation | Department of Gynecology of the Federal University of São Paulo, São Paulo, Brazil. | pt_BR |
Affilliation | Division of Epidemiology and Biostatistics, ICMR-National AIDS Research Institute, Indian Council of Medical Research, Pune, India. | pt_BR |
Affilliation | Radboud University Nijmegen, Medical Centre, Department of Urology, Nijmegen, Netherlands. | pt_BR |
Affilliation | Department of Gynecology and Obstetrics, General University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic. | pt_BR |
Affilliation | Division of Infectious Disease, University of South Florida, Tampa, FL, USA. | pt_BR |
Affilliation | Women's Healthcare Center, Instituto de Medicina Integral Professor Fernando Figueira, Recife, PE, Brazil; Cytopathology Division, Public Health Laboratory of the State of Pernambuco, Recife, PE, Brazil. | pt_BR |
Affilliation | International Agency for Research on Cancer, Lyon, France. | pt_BR |
Subject | Cervical cancer | pt_BR |
Subject | HPV | pt_BR |
Subject | HSIL | pt_BR |
Subject | HIV | pt_BR |
Embargo date | 2020-11-01 | |