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https://www.arca.fiocruz.br/handle/icict/34853
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ArtigoDireito Autoral
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2020-08-16
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- INI - Artigos de Periódicos [3400]
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UPDATE ON NEUROLOGICAL MANIFESTATIONS OF HTLV-1 INFECTION
HTLV-1
Myelopathy
Myelitis
Polymyositis
Polyneuropathy
Araujo, Abelardo Q-C. | Data do documento:
2015
Autor(es)
Afiliação
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil / Federal University of Rio de Janeiro. Deolindo Couto Institute of Neurology. Rio de Janeiro, RJ, Brasil.
Resumo em Inglês
The human T cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that infects 10–20 million persons around the world. Initially associated with the hematological malignancy adult T cell leukemia/lymphoma (ATLL), HTLV-1 is also the cause of a chronic progressive myelopathy named “HTLV-1-associated myelopathy/tropical spastic paraparesis” (HAM/TSP). HAM/TSP arises as the tip of the iceberg of an assortment of neurological syndromes triggered by the virus such as inflammatory myopathies, polyneuropathies, amyotrophic lateral sclerosis (ALS)-like syndromes, dysautonomia, and cognitive impairment. HAM/TSP typifies a chronic progressive spastic paraparesis with neurogenic bladder and minimal sensory signs. The neuropathology of HAM/TSP is concentrated in the thoracic spinal cord and is typically biphasic. Initially, there is a perivascular lymphocytic cuffing and mild parenchymal mononuclear infiltrates. Subsequently, this is replaced by gliosis and scarring. The neuropathogenesis of HTLV-1 is still partially understood. At present, the therapy of HAM/TSP remains basically symptomatic.
Palavras-chave em inglês
HTLV-1-associated myelopathy/tropical spastic paraparesisHTLV-1
Myelopathy
Myelitis
Polymyositis
Polyneuropathy
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