Author | Azadi, M. | |
Author | Bishai, D. M. | |
Author | Dowdy, D. W. | |
Author | Moulton, L. H. | |
Author | Cavalcante, S. | |
Author | Saraceni, V. | |
Author | Pacheco, A. G. | |
Author | Cohn, S. | |
Author | Chaisson, R. E. | |
Author | Durovni, B. | |
Author | Golub, J. E. | |
Access date | 2019-08-30T14:00:05Z | |
Available date | 2019-08-30T14:00:05Z | |
Document date | 2014 | |
Citation | AZADI, M. et al. Cost-effectiveness of tuberculosis screening and isoniazid treatment in the TB/HIV in Rio (THRio) study. International Journal of Tuberculosis and Lung Disease, v. 18, n. 12, p. 1443-1448, 2014. | pt_BR |
ISSN | 1027-3719 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/35219 | |
Description | Solange Cavalcanti. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. | pt_BR |
Abstract in Portuguese | OBJECTIVE: To estimate the incremental cost-effectiveness of tuberculosis (TB) screening and isoniazid
preventive therapy (IPT) among human immunodeficiency virus (HIV) infected adults in Rio de Janeiro,
Brazil. DESIGN: We used decision analysis, populated by data from a cluster-randomized trial, to project the costs (in 2010 USD) and effectiveness (in disability-adjusted life years [DALYs] averted) of training health care workers to implement the tuberculin skin test (TST), followed by IPT for TST-positive patients with no evidence of active TB. This intervention was compared to a baseline of usual care. We used time horizons of 1 year for the intervention and 20 years for disease outcomes, with all future DALYs and medical costs discounted at 3% per year. RESULTS: Providing this intervention to 100 people would avert 1.14 discounted DALYs (1.57 undiscounted DALYs). The median estimated incremental cost-effectiveness ratio was $2273 (IQR $1779–$3135) per DALY averted, less than Brazil’s 2010 per capita gross domestic product (GDP) of $11 700. Results were most sensitive to the cost of providing the training. CONCLUSION: Training health care workers to screen HIV-infected adults with TST and provide IPT to those with latent tuberculous infection can be considered cost-effective relative to the Brazilian GDP per capita. | pt_BR |
Language | eng | pt_BR |
Publisher | International Union Against Tuberculosis and Lung Disease | pt_BR |
Rights | open access | pt_BR |
Title | Cost-effectiveness of tuberculosis screening and isoniazid treatment in the TB/HIV in Rio (THRio) study | pt_BR |
Type | Article | pt_BR |
DOI | 10.5588/ijtld.14.0108 | |
Affilliation | Johns Hopkins Bloomberg School of Public Health. Department of Population Family and Reproductive Health. Baltimore, MD, USA. | pt_BR |
Affilliation | Johns Hopkins Bloomberg School of Public Health. Department of Population Family and Reproductive Health. Baltimore, MD, USA. | pt_BR |
Affilliation | Johns Hopkins School of Public Health. Department of Epidemiology. Baltimore, MD, USA. | pt_BR |
Affilliation | Johns Hopkins Bloomberg School of Public Health. Department of International Health. Baltimore, MD, USA / Johns Hopkins University School of Medicine. Center for Tuberculosis Research. Department of Medicine. Baltimore, MD, USA. | pt_BR |
Affilliation | Municipal Health Secretariat. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Presdiência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Municipal Health Secretariat. Rio de Janeiro, RJ, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Johns Hopkins Bloomberg School of Public Health. Department of International Health. Baltimore, MD, USA / Johns Hopkins University School of Medicine. Center for Tuberculosis Research. Department of Medicine. Baltimore, MD, USA. | pt_BR |
Affilliation | Johns Hopkins School of Public Health. Department of Epidemiology. Baltimore, MD, USA / Johns Hopkins Bloomberg School of Public Health. Department of International Health. Baltimore, MD, USA / Johns Hopkins University School of Medicine. Center for Tuberculosis Research. Department of Medicine. Baltimore, MD, USA / Johns Hopkins University School of Medicine. Center for Tuberculosis Research. Department of Medicine. Baltimore, MD, USA. | pt_BR |
Affilliation | Johns Hopkins University School of Medicine. Center for Tuberculosis Research. Department of Medicine. Baltimore, MD, USA / Federal University of Rio de Janeiro. Rio de Janeiro, RJ, Brazil. | pt_BR |
Affilliation | Johns Hopkins School of Public Health. Department of Epidemiology. Baltimore, MD, USA / Johns Hopkins Bloomberg School of Public Health. Department of International Health. Baltimore, MD, USA / Johns Hopkins University School of Medicine. Center for Tuberculosis Research. Department of Medicine. Baltimore, MD, USA / Johns Hopkins University School of Medicine. Center for Tuberculosis Research. Department of Medicine. Baltimore, MD, USA. | pt_BR |
Subject | Brazil | pt_BR |
Subject | TB-HIV co-infection | pt_BR |
Subject | Economic analysis | pt_BR |
Subject | IPT | pt_BR |
Subject | Skin tests | pt_BR |
e-ISSN | 1815-7920 | |
Embargo date | 2020-02-29 | |