Author | Leandro, Ana Cristina C. S. L. | |
Author | Rocha, Márcia Andrade | |
Author | Lamoglia-Souza, Andreia | |
Author | VandeBerg, John L. | |
Author | Rolla VC, Valeria Cavalcanti | |
Author | Bonecini-Almeida, Maria da Gloria | |
Access date | 2019-09-27T14:41:49Z | |
Available date | 2019-09-27T14:41:49Z | |
Document date | 2013 | |
Citation | LEANDRO, Ana Cristina C. S. L. et al. No association of IFNG+874T/A SNP and NOS2A-954G/C SNP variants with nitric oxide radical serum levels or susceptibility to tuberculosis in a Brazilian population subset. Biomed Research International, p. 1-7, 2013. | pt_BR |
ISSN | 2314-6133 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/35962 | |
Language | eng | pt_BR |
Publisher | Hindawi | pt_BR |
Rights | open access | pt_BR |
Title | No association of IFNG+874T/A SNP and NOS2A-954G/C SNP variants with nitric oxide radical serum levels or susceptibility to tuberculosis in a Brazilian population subset | pt_BR |
Type | Article | pt_BR |
DOI | 10.1155/2013/901740 | |
Abstract | Tuberculosis (TB) is one of the most common infectious diseases in the world. Mycobacterium tuberculosis infection leads to pulmonary active disease in approximately 5–10% of exposed individuals. Both bacteria- and host-related characteristics influence latent infection and disease. Host genetic predisposition to develop TB may involve multiple genes and their polymorphisms. It was reported previously that interferon gamma (IFN-𝛾) and nitric oxide synthase 2 (NOS2) are expressed on alveolar macrophages from TB patients and are responsible for bacilli control; thus, we aimed this study at genotyping single nucleotide polymorphisms IFNG+874T/A SNP and NOS2A-954G/C SNP to estimate their role on TB susceptibility and determine whether
these polymorphisms influence serum nitrite and NO𝑥− production. This case-control study enrolled 172 TB patients and 179 Thealthy controls. Neither polymorphism was associated with susceptibility to TB. NOS2A-954G/C SNP was not associated with serum levels of nitrite and NO𝑥−. These results indicate that variants of IFNG+874T/A SNP and NOS2A-954G/C SNP do not influence TB susceptibility or the secretion of nitric oxide radicals in the study population. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Imunologia e Imunogenética em Doenças Infecciosas. Rio de Janeiro, RJ, Brasil / Texas Biomedical Research Institute. Department of Genetics and Southwest National Primate Research Center. San Antonio, TX, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Imunologia e Imunogenética em Doenças Infecciosas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Imunologia e Imunogenética em Doenças Infecciosas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Texas Biomedical Research Institute. Department of Genetics and Southwest National Primate Research Center. San Antonio, TX, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Imunologia e Imunogenética em Doenças Infecciosas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Imunologia e Imunogenética em Doenças Infecciosas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Tuberculosis | pt_BR |
Subject | IFNG+874T/A SNP | pt_BR |
Subject | NOS2A-954G/C SNP | pt_BR |
e-ISSN | 2314-6141 | |