Author | Stoszek, Sonia K. | |
Author | Duarte, Geraldo | |
Author | Hance, Laura Freimanis | |
Author | Pinto, Jorge | |
Author | Gouvea, Maria I. | |
Author | Cohen, Rachel A. | |
Author | Santos, Breno | |
Author | Teles, Elizabete | |
Author | Succi, Regina | |
Author | Alarcon, Jorge O. | |
Author | Read, Jennifer S. | |
Author | NISDI Perinatal/LILAC Study Group | |
Access date | 2019-10-03T13:38:15Z | |
Available date | 2019-10-03T13:38:15Z | |
Document date | 2013 | |
Citation | STOSZEK, Sonia K. et al. Trends in the management and outcome of HIV-1-infected women and their infants in the NISDI Perinatal and LILAC cohorts, 2002-2009. International Journal of Gynecology and Obstetrics, v. 122, n. 1, p. 37-43, July 2013. | pt_BR |
ISSN | 0020-7292 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/36123 | |
Description | Maria I. Gouvea. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. | pt_BR |
Language | eng | pt_BR |
Publisher | Wiley | pt_BR |
Rights | open access | pt_BR |
Title | Trends in the management and outcome of HIV-1-infected women and their infants in the NISDI Perinatal and LILAC cohorts, 2002-2009 | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.ijgo.2012.12.021 | |
Abstract | Objective — To describe temporal management and outcome trends among HIV-1-infected pregnant women and their infants enrolled in the NISDI Perinatal and LILAC cohorts. Methods — A prospective cohort of 1548 HIV-1-infected pregnant women and their 1481 singleton live-born infants was analyzed. Participants were enrolled at 24 Latin American and Caribbean sites and followed-up for at least 6 months postpartum. Variables were compared by 2-year enrollment periods from September 27, 2002, to June 30, 2009, using logistic and linear regression modeling. Results — Antiretroviral (ARV) use during pregnancy remained high (99.0%). ARVs became increasingly used for treatment (P<0.001). Regimens containing 2 nucleoside reverse transcriptase
inhibitors plus a protease inhibitor became more common in later years (P<0.001). The proportion of women with viral loads below 1000 copies/mL at hospital discharge after delivery (HD) increased over time (P=0.0031). Median CD4 lymphocyte counts also rose at HD, from 441 cell/mm3 to 515 cells/mm3 (P<0.05). Elective cesarean deliveries increased from 30.5% to 42.0% (P=0.018). Most infants received ARV prophylaxis (99.7%). Few infants were breastfed (0.5%) or became infected with HIV-1 (1.2%). Conclusion —The results indicate that national HIV-1 treatment and transmission prevention policies are effective among patients with healthcare access in the region. | pt_BR |
Affilliation | Westat. Health Studies Sector. Rockville, MD, USA. | pt_BR |
Affilliation | University of São Paulo. Faculty of Medicine of Ribeirão Preto. Ribeirão Preto, SP, Brazil. | pt_BR |
Affilliation | Westat. Health Studies Sector. Rockville, MD, USA. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Department of Pediatrics. Immunology Division. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Hospital dos Servidores do Estado - Saúde. Serviço de Doenças Infecciosas e Parasitárias. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Westat. Health Studies Sector. Rockville, MD, USA. | pt_BR |
Affilliation | Hospital Nossa Senhora da Conceição. Serviço de Infectologia. Porto Alegre, RJ, Brasil. | pt_BR |
Affilliation | Hospital Femina. Serviço de Infectologia. Porto Alegre, RS, Brasil. | pt_BR |
Affilliation | Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasil. | pt_BR |
Affilliation | University of San Marcos. Instituto de Medicina Tropical Daniel Alcides Carrion. Lima, Peru. | pt_BR |
Affilliation | National Institutes of Health. Department of Health and Human Services. Eunice Kennedy Shriver National Institute of Child Health and Human Development. Pediatric, Adolescent, and Maternal AIDS Branch. Bethesda, MD, USA / National Vaccine Program Office. Department of Health and Human Services. Office of the Secretary. Office of the Assistant Secretary of Health. Washington, DC, USA. | pt_BR |
Subject | Antiretroviral | pt_BR |
Subject | HIV-1 | pt_BR |
Subject | Latin America | pt_BR |
Subject | Mother-to-child transmission | pt_BR |
Subject | Prophylaxis | pt_BR |
Subject | Treatment | pt_BR |
e-ISSN | 1879-3479 | |
Embargo date | 2020-10-03 | |