Author | Castro Neto, Artur L. | |
Author | Brito, Adriana N. A. L. M. | |
Author | Rezende, Antonio M. | |
Author | Magalhães, Franklin B. | |
Author | Melo Neto, Osvaldo P. de | |
Access date | 2019-10-07T13:37:42Z | |
Available date | 2019-10-07T13:37:42Z | |
Document date | 2019 | |
Citation | CASTRO NETO, Artur L. et al. In silico characterization of multiple genes encoding the GP63 virulence protein from Leishmania braziliensis: identification of sources of variation and putative roles in immune evasion. BMC Genomics, v. 20, n. 1, p. 1-17 Feb. 2019. | pt_BR |
ISSN | 1471-2164 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/36220 | |
Language | eng | pt_BR |
Rights | open access | pt_BR |
Title | In silico characterization of multiple genes encoding the GP63 virulence protein from Leishmania braziliensis: identification of sources of variation and putative roles in immune evasion | pt_BR |
Type | Article | pt_BR |
DOI | 10.1186/s12864-019-5465-z | |
Abstract | The leishmaniasis are parasitic diseases caused by protozoans of the genus Leishmania, highly divergent eukaryotes, characterized by unique biological features. To survive in both the mammalian hosts and insect vectors, these pathogens make use of a number of mechanisms, many of which are associated with parasite specific proteases. The metalloprotease GP63, the major Leishmania surface antigen, has been found to have multiple functions required for the parasite's survival. GP63 is encoded by multiple genes and their copy numbers vary considerably between different species and are increased in those from the subgenus Viannia, including L. braziliensis. | pt_BR |
Affilliation | Universidade Federal de Pernambuco. Recife, PE, Brasil / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
Affilliation | Centro Universitário Tabosa de Almeida - ASCES/UNITA. Caruaru, PE, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
Subject | GP63 | pt_BR |
Subject | Leishmania braziliensis | pt_BR |
Subject | Virulence proteins | pt_BR |
DeCS | Sequência de Aminoácidos | pt_BR |
DeCS | Cromossomos / genética | pt_BR |
DeCS | Simulação por Computador | pt_BR |
DeCS | Epitopos de Linfócito B / imunologia | pt_BR |
DeCS | Evolução Molecular | pt_BR |
DeCS | Variação Genética | pt_BR |
DeCS | Evasão da Resposta Imune / genética | pt_BR |
DeCS | Leishmania braziliensis / genética | pt_BR |
DeCS | Leishmania braziliensis / imunologia | pt_BR |
DeCS | Leishmania braziliensis / patogenicidade | pt_BR |
DeCS | Metaloendopeptidases / química | pt_BR |
DeCS | Metaloendopeptidases / genética | pt_BR |
DeCS | Recombinação Genética | pt_BR |
DeCS | Homologia de Sequência do Ácido Nucleico | pt_BR |
DeCS | patogenicidade / genética | pt_BR |