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https://www.arca.fiocruz.br/handle/icict/36265
A SINGLE INTRODUCTION OF YERSINIA PESTIS TO BRAZIL DURING THE 3RD PLAGUE PANDEMIC
DNA Bacteriano / genética
Variação Genética
Genoma Bacteriano
História do Século XIX
História do Século XX
Humanos
Pandemias / história
Filogenia
Filogeografia
Peste / epidemiologia
Peste / história
Peste / microbiologia
Polimorfismo de Nucleotídeo Único
Análise Espaço-Temporal
Yersinia pestis / classificação
Yersinia pestis / genética
Yersinia pestis / isolamento & purificação
Author
Affilliation
Northern Arizona University. The Pathogen and Microbiome Institute. Flagstaff, Arizona, USA.
Northern Arizona University. The Pathogen and Microbiome Institute. Flagstaff, Arizona, USA.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães, Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães, Recife, PE, Brasil.
Northern Arizona University. The Pathogen and Microbiome Institute. Flagstaff, Arizona, USA.
Northern Arizona University. The Pathogen and Microbiome Institute. Flagstaff, Arizona, USA.
Northern Arizona University. The Pathogen and Microbiome Institute. Flagstaff, Arizona, USA.
Northern Arizona University. The Pathogen and Microbiome Institute. Flagstaff, Arizona, USA.
Northern Arizona University. The Pathogen and Microbiome Institute. Flagstaff, Arizona, USA.
Northern Arizona University. The Pathogen and Microbiome Institute. Flagstaff, Arizona, USA.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães, Recife, PE, Brasil.
Northern Arizona University. The Pathogen and Microbiome Institute. Flagstaff, Arizona, USA / Translational Genomics Research Institute North. Flagstaff, Arizona, USA.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães, Recife, PE, Brasil.
Northern Arizona University. The Pathogen and Microbiome Institute. Flagstaff, Arizona, USA.
Northern Arizona University. The Pathogen and Microbiome Institute. Flagstaff, Arizona, USA.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães, Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães, Recife, PE, Brasil.
Northern Arizona University. The Pathogen and Microbiome Institute. Flagstaff, Arizona, USA.
Northern Arizona University. The Pathogen and Microbiome Institute. Flagstaff, Arizona, USA.
Northern Arizona University. The Pathogen and Microbiome Institute. Flagstaff, Arizona, USA.
Northern Arizona University. The Pathogen and Microbiome Institute. Flagstaff, Arizona, USA.
Northern Arizona University. The Pathogen and Microbiome Institute. Flagstaff, Arizona, USA.
Northern Arizona University. The Pathogen and Microbiome Institute. Flagstaff, Arizona, USA.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães, Recife, PE, Brasil.
Northern Arizona University. The Pathogen and Microbiome Institute. Flagstaff, Arizona, USA / Translational Genomics Research Institute North. Flagstaff, Arizona, USA.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães, Recife, PE, Brasil.
Northern Arizona University. The Pathogen and Microbiome Institute. Flagstaff, Arizona, USA.
Abstract
Yersinia pestis was introduced to Brazil during the third plague pandemic and currently exists in several recognized foci. There is currently limited available phylogeographic data regarding Y. pestis in Brazil. We generated whole genome sequences for 411 Y. pestis strains from six Brazilian foci to investigate the phylogeography of Y. pestis in Brazil; these strains were isolated from 1966 to 1997. All 411 strains were assigned to a single monophyletic clade within the 1.ORI population, indicating a single Y. pestis introduction was responsible for the successful establishment of endemic foci in Brazil. There was a moderate level of genomic diversity but little population structure among the 411 Brazilian Y. pestis strains, consistent with a radial expansion wherein Y. pestis spread rapidly from the coast to the interior of Brazil and became ecologically established. Overall, there were no strong spatial or temporal patterns among the Brazilian strains. However, strains from the same focus tended to be more closely related and strains isolated from foci closer to the coast tended to fall in more basal positions in the whole genome phylogeny than strains from more interior foci. Overall, the patterns observed in Brazil are similar to other locations affected during the 3rd plague pandemic such as in North America and Madagascar.
DeCS
Brasil / epidemiologiaDNA Bacteriano / genética
Variação Genética
Genoma Bacteriano
História do Século XIX
História do Século XX
Humanos
Pandemias / história
Filogenia
Filogeografia
Peste / epidemiologia
Peste / história
Peste / microbiologia
Polimorfismo de Nucleotídeo Único
Análise Espaço-Temporal
Yersinia pestis / classificação
Yersinia pestis / genética
Yersinia pestis / isolamento & purificação
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