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https://www.arca.fiocruz.br/handle/icict/36330
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ArtigoDireito Autoral
Acesso restrito
Data de embargo
2022-01-01
Coleções
- IOC - Artigos de Periódicos [12500]
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EXPLORING THE ROLE OF INSECT HOST FACTORS IN THE DYNAMICS OF TRYPANOSOMA CRUZI-RHODNIUS PROLIXUS INTERACTIONS
Autor(es)
Afiliação
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil.
University of Wales. Department of Biological Sciences. Swansea, Wales, UK.
Institut de Biologie Moleculaire et Cellulaire. CNRS. Strasbourg, France.
Universidade Federal Fluminense. Departamento de Biologia Geral. Niterói, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil.
University of Wales. Department of Biological Sciences. Swansea, Wales, UK.
Institut de Biologie Moleculaire et Cellulaire. CNRS. Strasbourg, France.
Universidade Federal Fluminense. Departamento de Biologia Geral. Niterói, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil.
Resumo em Inglês
Members of the subfamily Triatominae, family Reduviidae, comprise a large number of insect species of which some are vectors of Trypanosoma cruzi, the causative agent of Chagas' disease. This article outlines research on the process of transformation and the dynamics of developmental stages of Trypanosoma cruzi in the triatomine insect hosts. Special attention is given to the interactions of parasites with gut molecules, and the gut environment, and with host developmental physiology and intestinal organization. The vector insect's permissiveness to Trypanosoma cruzi, which develops in the vector gut, largely depends on the host nutritional state, the parasite strain, trypanolytic compounds, digestive enzymes, lectins, resident bacteria in the gut and the endocrine system of the insect vector. Finally, the mechanisms of these interactions and their significance for Trypanosoma cruzi transmission are discussed.
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