Author | Robertson, K. | |
Author | Jiang, H. | |
Author | Kumwenda, J. | |
Author | Supparatpinyo, K. | |
Author | Evans, S. | |
Author | Campbell, T. B. | |
Author | Price, R. | |
Author | Tripathy, S. | |
Author | Kumarasamy, N. | |
Author | La Rosa, A. | |
Author | Santos, B. | |
Author | The 5199 study team | |
Author | Silva, M. T. T. | |
Author | Montano, S. | |
Author | Kanyama, C. | |
Author | Faesen, S. | |
Author | Murphy, R. | |
Author | Hall, C. | |
Author | Marra, C. M. | |
Author | Marcus, C. | |
Author | Berzins, B. | |
Author | Allen, R. | |
Author | Housseinipour, M. | |
Author | Amod, F. | |
Author | Sanne, I. | |
Author | Hakim, J. | |
Author | Walawander, A. | |
Author | Nair, A. | |
Author | The AIDS Clinical Trials Group | |
Access date | 2019-10-15T15:16:30Z | |
Available date | 2019-10-15T15:16:30Z | |
Document date | 2012 | |
Citation | ROBERTSON, K. et al. Improved neuropsychological and neurological functioning across three antiretroviral regimens in diverse resource-limited settings: AIDS Clinical Trials Group study A5199, the International Neurological Study. Clinical Infectious Diseases, v. 55, n. 6, p. 868-876, 2012. | pt_BR |
ISSN | 1058-4838 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/36457 | |
Description | Marcus Tulius Teixeira da Silva. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
1 University of North Carolina, Chapel Hill, 2 Harvard University, Boston, Massachusetts; 3 Queen Elizabeth Central Hospital, Blantyre, Malawi; 4 Chiang Mai University, Thailand; 5 University of Colorado Denver, Aurora, 6 University of California San Francisco; 7 National AIDS Research Institute, Pune, 8 YRGCARE Medical Center, Chennai, India; 9 Asociacion Civil Impacta Salud y Educacion, Lima, Peru; 10AIDS Clinical Trials Group, Division of AIDS, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; 11Hospital Nossa Senhora da Conceicao, Porto Alegre, 12Fiocruz, Rio De Janeiro, Brazil; 13Naval Medical Research Unit Six (NAMRU-6); 14Kamuza Central Hospital, Lilongwe, Malawi; 15Wits HIV Clinical Research Site, Helen Joseph Hospital, Johannesburg, South Africa; 16Northwestern University, Chicago, Illinois, 17University of Washington, Seattle, 18Social Scientific Systems, Bethesda, Maryland; 19University of KwaZulu Natal Medical School HIV Clinic, Durban, South Africa; 20University of Zimbabwe, Harare; and 21Frontier Science and Technology Research Foundation, Amherst, New York | pt_BR |
Language | eng | pt_BR |
Publisher | Oxford University Press | pt_BR |
Rights | open access | pt_BR |
Title | Improved neuropsychological and neurological functioning across three antiretroviral regimens in diverse resource-limited settings: AIDS Clinical Trials Group study A5199, the International Neurological Study | pt_BR |
Type | Article | pt_BR |
DOI | 10.1093/cid/cis507 | |
Abstract | Background - AIDS Clinical Trials Group (ACTG) A5199 compared the neurological and neuropsychological
(NP) effects of 3 antiretroviral regimens in participants infected with human immunodeficiency virus type 1
(HIV-1) in resource-limited settings. Methods. Participants from Brazil, India, Malawi, Peru, South Africa, Thailand, and Zimbabwe were randomized to 3 antiretroviral treatment arms: A (lamivudine-zidovudine plus efavirenz, n = 289), B (atazanavir, emtricitabine, and didanosine-EC, n = 293), and C (emtricitabine-tenofovir-disoproxil fumarate plus efavirenz, n = 278) as part of the ACTG PEARLS study (A5175). Standardized neurological and neuropsychological (NP) screening examinations (grooved pegboard, timed gait, semantic verbal fluency, and finger tapping) were administered every 24 weeks from February 2006 to May 2010. Associations with neurological and neuropsychological function were estimated from linear and logistic regression models using generalized estimating equations. Results - The median weeks on study was 168 (Q1 = 96, Q3 = 192) for the 860 participants. NP test scores improved (P < .05) with the exception of semantic verbal fluency. No differences in neurological and neuropsychological functioning between treatment regimens were detected (P > .10). Significant country effects were noted on all NP tests and neurological outcomes (P < .01). Conclusions - The study detected no significant differences in neuropsychological and neurological outcomesbetween randomized ART regimens. Significant improvement occurred in neurocognitive and neurological functioning over time after initiation of ARTs. The etiology of these improvements is likely multifactorial, reflecting reduced central nervous system HIV infection, better general health, and practice effects. This study suggests that treatment with either of the World Health Organization –recommended first-line antiretroviral regimens in resource-limited settings will improve neuropsychological functioning and reduce neurological dysfunction. | pt_BR |
Affilliation | Múltipla - ver em Notas. | pt_BR |
Subject | HIV | pt_BR |
Subject | Antiretroviral regimens | pt_BR |
Subject | Neurological effects | pt_BR |
Subject | Neuropsychological effects | pt_BR |
e-ISSN | 1537-6591 | |
Embargo date | 2020-10-15 | |