Author | Reis, Luis Felipe | |
Author | Ventura, Túlio Galvão | |
Author | Souza, Sônia Oliveira | |
Author | Arana-Pino, Arturo | |
Author | Machado, Marcelo Pelajo | |
Author | Pereira, Mario José S. | |
Author | Lenzi, Henrique Leonel | |
Author | Conceição, Maria José | |
Author | Takiya, Christina Maeda | |
Access date | 2011-12-26T15:08:18Z | |
Available date | 2011-12-26T15:08:18Z | |
Document date | 2001 | |
Citation | REIS, Luis Felipe et al. Quantitave and qualitative interferences of pentoxifillyne on hepatic Schistosoma mansoni granulomas: effects on extracellular matrix and eosinophil population. Memórias do Instituto Oswaldo Cruz, v. 96, supl., p. 107-112, 2001. | pt_BR |
ISSN | 0074-0276 | |
URI | https://www.arca.fiocruz.br/handle/icict/3723 | |
Language | eng | pt_BR |
Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz | pt_BR |
Rights | open access | pt_BR |
Title | Quantitave and Qualitative Interferences of Pentoxifillyne on Hepatic Schistosoma mansoni Granulomas: Effects on Extracellular Matrix and Eosinophil Population | pt_BR |
Type | Article | pt_BR |
DOI | http://dx.doi.org/10.1590/S0074-02762001000900015 | |
Abstract | Mast cells and eosinophils actively participate in tissue repair and are prominent components of Schistosoma mansoni granulomas. Since pentoxifillyne (PTX) is an immunomodulatory and antifibrotic substance, we aimed to characterize, by morphological techniques, the effect of this drug on fibrosis developed inside murine hepatic schistosomal granulomatous reaction, beyond the quantification of eosinophil and mast cell populations. The drug (1 mg/100 g animal weight) was administrated from 35 to 90 days post-infection, when the animals were killed. The intragranulomatous interstitial collagen network was analyzed by confocal laser scanning microscopy, the number of eosinophils and mast cells was quantified and the results were validated by t-student test. Treatment did not interfere on the granuloma evolution but caused a significant decrease in the total and involutive number of hepatic granulomas (p = 0.01 and 0.001, respectivelly), and in the intragranulomatous accumulation of eosinophils (p = 0.0001). Otherwise, the number of mast cells was not significantly altered (p = 0.9); however, it was positively correlated with the number of granulomatous structures (r = 0.955). In conclusion, PTX does not affect development and collagen deposition in S. mansoni murine granuloma, but decreases the intragranulomatous eosinophil accumulation possibly due to its immunomodulatory capability, interfering in cellular recruitment and/or differentiation. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil | pt_BR |
Subject | Mast Cell | pt_BR |
Subject | Eosinophil | pt_BR |
Subject | Collagen | pt_BR |
Subject | Pentoxifylline | pt_BR |
Subject | Schistosoma mansoni | pt_BR |
DeCS | Eosinófilos | pt_BR |
DeCS | Schistosoma mansoni | pt_BR |
DeCS | Colágeno | pt_BR |
DeCS | Mastócitos | pt_BR |