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https://www.arca.fiocruz.br/handle/icict/37503
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ArtigoDireito Autoral
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Data de embargo
2050-01-01
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NOROVIRUS-ASSOCIATED GASTROENTERITIS, PERNAMBUCO, NORTHEAST BRAZIL, 2014-2017
Brazil
Human NoV infection
Epidemiology
Molecular
Norovirus
Autor(es)
Afiliação
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil / Laboratório Central do Estado de Pernambuco. Departamento de Virologia. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil / Laboratório Central do Estado de Pernambuco. Departamento de Virologia. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil.
Resumo em Inglês
Norovirus (NoV) is currently the leading cause of non-bacterial gastroenteritis. In Brazil, few studies have characterized the molecular, epidemiological and clinical features of NoV-associated gastroenteritis. This study aimed to describe the molecular and clinicoepidemiological findings of NoV infections in patients of all ages throughout Pernambuco state, Northeast Brazil. Thus, 1,135 stool samples were analyzed from patients with gastroenteritis from Pernambuco state. NoV was detected by enzyme immunoassay (EIA) in 125 (11.01%) samples. Regarding gender distribution, 55 (44.00%) patients were female and 70 (56.00%) male. Their ages ranged from 5 days to 87 years, and the group most affected by NoV infection (88.00%) was children under three years. Complete clinical information was available for 88 out of 125 NoV-positive patients. Diarrhea was present in all patients and vomiting was reported in 60 patients (68.68%). Nine patients (10.22%) had bloody stools and 46 (52.27%) had fever, with temperatures ranging from 37.90ºC to 39.90ºC (mean 38.20ºC). NoV was detected mainly in the summer-autumn seasons. Genome sequencing and phylogenetic analyses identified four different NoV GII genotypes circulating in this area of the country. Therefore, our study provided valuable information about the clinics and epidemiology of NoV infection in tropical settings and will assist health authorities to develop better control strategies against this important pathogen. This article is protected by copyright. All rights reserved.
Palavras-chave em inglês
Acute gastroenteritisBrazil
Human NoV infection
Epidemiology
Molecular
Norovirus
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