| Author | Burth, Patricia | |
| Author | Younes-Ibrahim, Mauricio | |
| Author | Santos, Maria C. B. | |
| Author | Faria Neto, Hugo Caire C. | |
| Author | Faria, Mauro Velho de Castro | |
| Access date | 2019-12-04T14:56:21Z | |
| Available date | 2019-12-04T14:56:21Z | |
| Document date | 2005 | |
| Citation | BURTH, Patricia et al. Role of Nonesterified Unsaturated Fatty Acids in the Pathophysiological Processes of Leptospiral Infection. The Journal of Infectious Diseases, v. 191, p. 51-57, 2005. | pt_BR |
| ISSN | 1904-2013 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/37574 | |
| Language | eng | pt_BR |
| Publisher | Infectious Diseases Society of America. | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Leptospirose | pt_BR |
| Subject in Portuguese | Ácidos graxos não saturados | pt_BR |
| Subject in Portuguese | Processos fisiopatológicos | pt_BR |
| Subject in Portuguese | Infecção leptospiral | pt_BR |
| Title | Role of Nonesterified Unsaturated Fatty Acids in the Pathophysiological Processes of Leptospiral Infection | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1086/426455 | |
| Abstract | Organ malfunctions in patients with leptospirosis have been associated with the bacterial glycolipoprotein endotoxin and with its nonesterified unsaturated fatty acid (NEUFA) components. We examined the involvement of NEUFAs in the pathophysiological processes of leptospirosis. Patients showed a moderate increase in serum concentrations of oleic and linoleic acids but an important decrease in serum concentrations of albumin. A highly significant correlation between serum concentrations of creatinine or total bilirubin and the oleic-plus-linoleic acid : albumin ratio was revealed. We used the Na(+),K(+)-ATPase inhibitory property of NEUFAs to test the capacity of serum to prevent the cytotoxic effects of NEUFAs in vitro. Albumin solutions and serum samples from healthy volunteers, but not serum samples from severely affected patients, were able to revert the Na(+),K(+)-ATPase inhibition by oleic acid. On the basis of these data, we defined a "serum protection factor" that can be helpful in predicting NEUFA toxicity. Our data support the concept that the administration of human albumin to patients may be helpful in severe leptospirosis cases. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Celular e Molecular. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Laboratório Integrado de Nefrologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Departamento de Biologia Celular e Genética. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Nonesterified Unsaturated Fatty Acids | pt_BR |
| Subject | Pathophysiological Processes | pt_BR |
| Subject | Leptospiral Infection | pt_BR |
| Subject | Leptospirosis | pt_BR |
