Author | Martins, Sharon de Toledo | |
Author | Silveira, Guilherme Ferreira | |
Author | Alves, Lysangela Ronalte | |
Author | Santos, Claudia Nunes Duarte dos | |
Author | Bordignon, Juliano | |
Access date | 2019-12-12T19:25:22Z | |
Available date | 2019-12-12T19:25:22Z | |
Document date | 2012 | |
Citation | MARTINS, Sharon de Toledo et al. Dendritic cell apoptosis and the pathogenesis of dengue. Viruses, São Paulo, n. 4, p. 2736-2753, 2012. | pt_BR |
ISSN | 1999-4915 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/37921 | |
Language | En | En |
Publisher | MDPI | pt_BR |
Rights | open access | pt_BR |
Title | Dendritic cell apoptosis and the pathogenesis of dengue | pt_BR |
Type | Article | pt_BR |
DOI | 10.3390/v4112736 | |
Abstract | Dengue viruses and other members of the Flaviviridae family are emerging human pathogens. Dengue is transmitted to humans by Aedes aegypti female mosquitoes. Following infection through the bite, cells of the hematopoietic lineage, like dendritic cells, are the first targets of dengue virus infection. Dendritic cells (DCs) are key antigen presenting cells, sensing pathogens, processing and presenting the antigens to T lymphocytes, and triggering an adaptive immune response. Infection of DCs by dengue virus may induce apoptosis, impairing their ability to present antigens to T cells, and thereby contributing to dengue pathogenesis. This review focuses on general mechanisms by which dengue virus triggers apoptosis, and possible influence of DC-apoptosis on dengue disease severity. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Regulação da Expressão Gênica. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Regulação da Expressão Gênica. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Subject | Dendritic Cells | pt_BR |
Subject | Apoptosis | pt_BR |
Subject | Dengue Virus | pt_BR |
Subject in Spanish | Virus del Dengue | pt_BR |
DeCS | Células Dendríticas | pt_BR |
DeCS | Apoptose | pt_BR |
DeCS | Vírus da Dengue | pt_BR |