Use este identificador para citar ou linkar para este item:
https://www.arca.fiocruz.br/handle/icict/39061
Tipo de documento
ArtigoDireito Autoral
Acesso aberto
Data de embargo
2021-01-08
Coleções
- INI - Artigos de Periódicos [3397]
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SWIMMING TRAINING ATTENUATES REMODELING, CONTRACTILE DYSFUNCTION AND CONGESTIVE HEART FAILURE IN RATS WITH MODERATE AND LARGE MYOCARDIAL INFARCTIONS
Heart failure
Myocardial infarction
Swimming training
Autor(es)
Afiliação
São Paulo Adventist University. Department of Physiology. São Paulo, SP, Brazil / Federal University of São Paulo. Department of Physiology. São Paulo, SP, Brazil.
Federal University of São Paulo. Department of Physiology. São Paulo, SP, Brazil.
Federal University of São Paulo. Department of Physiology. São Paulo, SP, Brazil.
Federal University of São Paulo. Department of Physiology. São Paulo, SP, Brazil.
Federal University of São Paulo. Department of Physiology. São Paulo, SP, Brazil.
Federal University of São Paulo. Department of Physiology. São Paulo, SP, Brazil.
Federal University of São Paulo. Department of Physiology. São Paulo, SP, Brazil.
Resumo em Inglês
1. The aim of the present study was to evaluate the effect of swimming on myocardial remodelling after myocardial infarction (MI) in female rats induced by coronary occlusion, which was not performed in sham rats. 2. Rats were divided in six groups, three sedentary (sham (SSh; n=14), moderate infarct (SMI; n=8) and large infarct (SLI; n=10) and three trained (sham (TSh; n=16), moderate infarct (TMI; n=9) and large infarct (TLI; n=8)) groups.Training (8 weeks, 60 min/day, 5 days/week) was initiated 4 weeks after MI or sham operation. Training did not affect mortality rate, but attenuated the increases in atrial/body weight (SSh: 0.07±0.02; TSh: 0.07±0.02; SMI: 0.11±0.03; TMI:0.09±0.03; SLI: 0.17±0.09; TLI: 0.10±0.05 mg/g) and right ventricular/bodyweight (SSh: 0.15±0.02; TSh: 0.17±0.02;SMI: 0.17±0.07; TMI: 0.20±0.03; SLI: 0.29±0.13; TLI: 0.22±0.08 mg/g) ratios. Myocardial infarction increased pulmonary and myocardial water content in infarcted sedentary animals, whereas no changes were observed in trained infarctedrats. Sedentary infarcted rats showed inotropic and lusitropic depression proportional to the size of the infarct (SSh>SMI>SLI), whereas no differences were noted in trained rats(TLI=TMI=TSh). Indeed, in sedentary rats there was depression of +dT/dt (SSh: 68±25; TSh: 72±21; SMI: 53±20; TMI:77±30; SLI: 33±15; TLI: 57±22 g/mm2 per s) and –dT/dt (SSh:33±13; TSh: 36±11; SMI: 24±5; TMI: 35±11; SLI: 15±4;TLI: 32±11 g/mm2 per s) compared with trained rats.3. In conclusion, swimming clearly favoured post-MI cardiac remodelling, attenuated myocardial hypertrophy, contractile and relaxation dysfunction and prevented pulmonary congestion.
Palavras-chave em inglês
Contractile dysfunctionHeart failure
Myocardial infarction
Swimming training
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