Author | Camera, Patricia de Oliveira | |
Author | Junger, Juliana | |
Author | Pires, Felipe do Espírito Santo Silva | |
Author | Mattos, Marise | |
Author | Oliveira Neto, Manoel Pires | |
Author | Fernandes, Octavio | |
Author | Pirmez, Claude | |
Access date | 2020-01-16T12:16:37Z | |
Available date | 2020-01-16T12:16:37Z | |
Document date | 2006 | |
Citation | CAMERA, Patricia de Oliveira et al. Haematogenous dissemination of Leishmania (Viannia) braziliensis in human American tegumentary leishmaniasis. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 100, p. 1112-1117, 2006. | pt_BR |
ISSN | 0035-9203 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/39249 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | restricted access | |
Subject in Portuguese | Leishmaniose | pt_BR |
Subject in Portuguese | Leishmania (Viannia) braziliensis | pt_BR |
Subject in Portuguese | Persistência de parasitas | pt_BR |
Subject in Portuguese | Difusão hematogênica | pt_BR |
Subject in Portuguese | Leishmaniose tegumentar americana | pt_BR |
Subject in Portuguese | Brasil | pt_BR |
Title | Haematogenous dissemination of Leishmania (Viannia) braziliensis in human American tegumentary leishmaniasis | pt_BR |
Type | Article | |
DOI | 10.1016/j.trstmh.2006.02.014 | |
Abstract | One of the potential dangers of American tegumentary leishmaniasis (ATL) caused
by Leishmania (Viannia) braziliensis is the development of mucosal lesions. Haematogenous
dissemination of the parasite is the most likely mechanism to explain this occurrence, but
most attempts to isolate the parasite from blood have so far been unsuccessful. The presence
of Leishmania in peripheral blood was therefore evaluated by PCR using DNA samples isolated
from patients presenting active cutaneous or mucosal disease, and from individuals cured by
antimonial treatment as well as individuals without a past history of leishmaniasis but with a
positive Montenegro skin test, all living in L. (V.) braziliensis-endemic areas. Leishmania DNA
was found not only in those patients presenting active cutaneous (24.8%) or mucosal (35%)
lesions, but also in samples isolated from healed individuals (27.3%) as well as in asymptomatic
skin-test-positive residents of endemic areas (37.5%). Overall, PCR showed the presence of
parasite DNA in the blood of 26.2% of the 225 examined samples. These data suggest that persistence
of parasites within the host may last for many years and, rather than being a risk factor,
might be important in maintaining the protective response in those living in endemic areas. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Leishmaniasis | pt_BR |
Subject | American tegumentary leishmaniasis | pt_BR |
Subject | Leishmania (Viannia) braziliensis | pt_BR |
Subject | Parasite persistence | pt_BR |
Subject | Haematogenous dissemination | pt_BR |
Subject | Brazil | pt_BR |
e-ISSN | 1878-3503 | |
Embargo date | 2022-01-01 | |