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Autor | Reis, Jucineide Silva de Sena | pt_BR |
Autor | Bezerra, Débora Diniz | pt_BR |
Autor | Figueiredo, Camila A. | pt_BR |
Autor | Barreto, Maurício Lima | pt_BR |
Autor | Neves, Neuza Maria Alcântara | pt_BR |
Autor | Silva, Thiago Magalhães da | pt_BR |
Fecha de acceso | 2020-01-21T11:59:00Z | |
Fecha de disponibilización | 2020-01-21T11:59:00Z | |
Fecha de publicación | 2019 | |
Referencia | REIS, Jucineide Silva de Sena et al. Relationship between african biogeographical ancestry and Helicobacter pylori infection in children of a large latin american urban center. Helicobacter, v. 24, n. 6, p. 1-8, 30 Sept. 2019. | pt_BR |
ISSN | 1083-4389 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/39334 | |
Promoción | Department of Science and Technology (DECIT, Ministry of Health) and National Fund for Scientific and Technological Development (FNDCT, Ministry of Science and Technology), Funding of Studies and Projects (FINEP, Ministry of Science and Technology, Brazil) Project number: 403629/1425411/2750. In addition, financial support for this study was provided by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001. | pt_BR |
Idioma | eng | pt_BR |
Editor | Wiley | pt_BR |
Derechos de autor | restricted access | pt_BR |
Palabras clave en Portugués | ELISA | pt_BR |
Palabras clave en Portugués | Ancestralidade genética | pt_BR |
Palabras clave en Portugués | Raça | pt_BR |
Palabras clave en Portugués | Salvador-Brasil | pt_BR |
Palabras clave en Portugués | Soroprevalência | pt_BR |
Título | Relationship between african biogeographical ancestry and Helicobacter pylori infection in children of a large latin american urban center | en |
Tipo del documento | Article | pt_BR |
DOI | 10.1111/hel.12662 | pt_BR |
Resumen en Inglés | Background and Aim: The relationship between race/ethnicity and H pylori infection has been extensively reported, with a higher prevalence of infection observed in black individuals. Whether such differences are due to genetic factors underlying African ancestry remains to be clarified. In the present study, we evaluated the association between the proportion of individual African ancestry and H pylori infection in a sample of 1046 children living in a large Latin American urban center. Materials and Methods: Estimation of individual biogeographical ancestry was based on 370,539 SNPs and performed using the ADMIXTURE software. Multivariate logistic regression models and mediation analysis considering the influence of previously recognized socioenvironmental risk factors to H pylori infection were performed. All analyses were conducted using the statistical package STATA v.14.0. Results: Each 10% increase in the proportion of individual African ancestry was positively and independently associated with H pylori infection in our population (adjusted OR = 1.22, 95% CI = 1.10‐1.36, P < .001). Mediation analysis demonstrated that only 9.23% of the effect of the individual African ancestry on H pylori infection was explained by factors such as household income, the absence of street paving and crowding. Conclusions: The results suggest that genetic variants that covariate with African ancestry may explain an important part of the racial differences observed for the prevalence of H pylori infection. | en |
Afiliación | Universidade Estadual do Sudoeste da Bahia. Programa de Pós-Graduação em Genética, Biodiversidade e Conservação. Jequié, BA, Brasil. | pt_BR |
Afiliación | Universidade Estadual do Sudoeste da Bahia. Programa de Pós-Graduação em Genética, Biodiversidade e Conservação. Jequié, BA, Brasil. | pt_BR |
Afiliación | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil. | pt_BR |
Afiliación | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil. | pt_BR |
Afiliación | Universidade Estadual do Sudoeste da Bahia. Departamento de Ciências Biológicas. Laboratório de Biologia e Genética Humana. Jequié, BA, Brasil. | pt_BR |
Palavras clave en Inglês | ELISA | en |
Palavras clave en Inglês | Genetic ancestry | en |
Palavras clave en Inglês | Race | en |
Palavras clave en Inglês | Salvador-Brazil | en |
Palavras clave en Inglês | Seroprevalence | en |
e-ISSN | 1523-5378 | pt_BR |