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https://www.arca.fiocruz.br/handle/icict/39348
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ArtículoDerechos de autor
Acceso restringido
Fecha del embargo
2022-01-01
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- IOC - Artigos de Periódicos [12488]
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PHARMACOLOGIC EVIDENCE FOR THE INVOLVEMENT OF CENTRAL AND PERIPHERAL OPIOID RECEPTORS IN THE CARDIOPROTECTIVE EFFECTS OF FENTANYL
Receptores de opióides periféricos
Efeitos no sistema cardioprotetor
Fentanil
Peripheral opioid receptors
Cardioprotective effects
Fentanyl
Afiliación
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.
Resumen en ingles
BACKGROUND: We investigated the involvement of central and peripheral opioid receptors (OR) in the cardioprotective effects of fentanyl (FENT) in a model of myocardial ischemia/reperfusion injury associated with pharmacologically induced sympathetic overactivity in anesthetized rabbits. METHODS: Central sympathetic stimulation was achieved through intracerebroventricular injection of l-glutamate in animals submitted to 35 min of coronary occlusion followed by 120 min of reperfusion. Rabbits received naloxone HCl intracerebroventricularly or naloxone methiodide IV, a quaternary compound that does not cross the blood–brain barrier, 5 min before FENT treatment (5 or 50μg/kg, IV). RESULTS: Infarct area was reduced only by FENT 50 (from 51% ± 2% to 24% ± 2%). This protective effect was abolished by peripheral (42% ± 4%), but not central, OR blockade (32% ± 3%). The number of premature ventricular complexes during the ischemic period (54 ± 3) was reduced by FENT 50 (19 ± 7), an effect blunted by central (40 ± 3) but not peripheral (18 ± 7) blockade of OR. During reperfusion, the number of premature ventricular complexes (134 ± 50) was reduced to 9 ± 5 by FENT 50 and was prevented by central (42 ± 4) as well as peripheral (20 ± 11) OR blockade. The mortality rate (50%) and incidence of ventricular tachycardia (55%) were completely abolished by FENT 50. CONCLUSIONS: We conclude that fentanyl’s effects for limiting myocardial ischemic injury are mediated via peripheral ORs while opioid’s antiarrhythmic actions are mediated via central OR agonism.
Palabras clave en portugues
Evidência farmacológicaReceptores de opióides periféricos
Efeitos no sistema cardioprotetor
Fentanil
Palabras clave en ingles
Pharmacologic evidencePeripheral opioid receptors
Cardioprotective effects
Fentanyl
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