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https://www.arca.fiocruz.br/handle/icict/39708
Tipo
ArtículoDerechos de autor
Acceso restringido
Fecha del embargo
2025-01-01
Colecciones
- IOC - Artigos de Periódicos [12502]
Metadatos
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ANTIPARASITIC ACTIVITY OF AROMATIC DIAMIDINES IS RELATED TO APOPTOSIS-LIKE DEATH IN TRYPANOSOMA CRUZI
Trypanosoma cruzi
Apoptosis-like death
Trypanocidal compounds
Autor
Afiliación
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil.
Georgia State University. Department of Chemistry. Atlanta, GA, USA.
Georgia State University. Department of Chemistry. Atlanta, GA, USA.
Georgia State University. Department of Chemistry. Atlanta, GA, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil.
Georgia State University. Department of Chemistry. Atlanta, GA, USA.
Georgia State University. Department of Chemistry. Atlanta, GA, USA.
Georgia State University. Department of Chemistry. Atlanta, GA, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil.
Resumen en ingles
Two aromatic diamidines, furamidine (DB75) and its phenyl-substituted analogue (DB569), which exhibit trypanocidal activity, were assayed against Trypanosoma cruzi and were found to induce apoptosis-like death characteristics such as nuclear DNA condensation and fragmentation, decreased mitochondrial membrane potential and phosphatidylserine exposure. DB569 displays superior trypanocidal activity compared to furamidine and also had higher ability to induce apoptosis-like death in treated parasites. The present results showing apoptosis-like death in T. cruzi after treatment with both DB75 and DB569 make important contributions to the understanding of the mechanisms of the aromatic diamidines, which represent promising trypanocidal compounds.
Palabras clave en ingles
Aromatic diamidinesTrypanosoma cruzi
Apoptosis-like death
Trypanocidal compounds
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