Author | Souza, Elen M. de | |
Author | Oliveira, Gabriel M. | |
Author | Boykin, David W. | |
Author | Kumar, Arvind | |
Author | Hu, Qiyue | |
Author | Soeiro, Maria Nazaré C. | |
Access date | 2020-02-04T14:11:05Z | |
Available date | 2020-02-04T14:11:05Z | |
Document date | 2006 | |
Citation | SOUZA, Elen M. de et al. Trypanocidal activity of the phenyl-substituted analogue of furamidine DB569 against Trypanosoma cruzi infection in vivo. Journal of Antimicrobial Chemotherapy, v. 58, p. 610-614, July 2006. | pt_BR |
ISSN | 0305-7453 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/39710 | |
Language | eng | pt_BR |
Publisher | Oxford University Press | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Doença de Chagas | pt_BR |
Subject in Portuguese | Terapia | pt_BR |
Subject in Portuguese | Diamidinas aromáticas | pt_BR |
Subject in Portuguese | Camundongos infectados | pt_BR |
Title | Trypanocidal activity of the phenyl-substituted analogue of furamidine DB569 against Trypanosoma cruzi infection in vivo | pt_BR |
Type | Article | pt_BR |
DOI | 10.1093/jac/dkl259 | |
Abstract | Aromatic diamidines have been successfully used to combat a wide range of parasites that cause important human infections. One such compound is furamidine (DB75) and we recently reported that one of its analogues, an N-phenyl analogue (DB569), exhibits higher trypanocidal dose and time-dependent effects against different forms of Trypanosoma cruzi as compared with DB75. Our present aim was to investigate the efficacy of DB569 in a T. cruzi mouse model. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Georgia State University. Department of Chemistry. Atlanta, GA, USA. | pt_BR |
Affilliation | Georgia State University. Department of Chemistry. Atlanta, GA, USA. | pt_BR |
Affilliation | Georgia State University. Department of Chemistry. Atlanta, GA, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Aromatic diamidines | pt_BR |
Subject | Therapy | pt_BR |
Subject | Infected mice | pt_BR |
Subject | Chagas Disease | pt_BR |
e-ISSN | 1460-2091 | |
Embargo date | 2025-01-01 | |
xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |