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INTERNATIONAL PROSPECTIVE OBSERVATIONAL COHORT STUDY OF ZIKA IN INFANTS AND PREGNANCY (ZIP STUDY): STUDY PROTOCOL
Author
Lebov, Jill F.
Arias, Juan F.
Balmaseda, Angel
Britt, William
Cordero, José F.
Galvão, Luiz Augusto
Garces, Ana Lucía
Hambidge, K. Michael
Harris, Eva
Ko, Albert
Krebs, Nancy
Marques, Ernesto T. A.
Martinez, Alexander M.
McClure, Elizabeth
Miranda-Filho, Democrito B.
Moreira, Maria Elisabeth Lopes
Mussi-Pinhata, Marisa M.
Ochoa, Theresa J.
Osorio, Jorge E.
Scalabrin, Deolinda M. F.
Schultz-Cherry, Stacey
Seage, George R.
Stolka, Kristen
Ugarte-Gil, César Augusto
Vega, Carmen Milagros Velez
Welton, Michael
Ximenes, Ricardo
Zorrilla, Carmen
Arias, Juan F.
Balmaseda, Angel
Britt, William
Cordero, José F.
Galvão, Luiz Augusto
Garces, Ana Lucía
Hambidge, K. Michael
Harris, Eva
Ko, Albert
Krebs, Nancy
Marques, Ernesto T. A.
Martinez, Alexander M.
McClure, Elizabeth
Miranda-Filho, Democrito B.
Moreira, Maria Elisabeth Lopes
Mussi-Pinhata, Marisa M.
Ochoa, Theresa J.
Osorio, Jorge E.
Scalabrin, Deolinda M. F.
Schultz-Cherry, Stacey
Seage, George R.
Stolka, Kristen
Ugarte-Gil, César Augusto
Vega, Carmen Milagros Velez
Welton, Michael
Ximenes, Ricardo
Zorrilla, Carmen
Affilliation
Social, Statistical and Environmental Sciences, RTI International, Durham, NC, USA.
Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis.
Centro Nacional de Diagnostico y Referencia, Complejo Nacional de Salud, Managua, Nicaragua.
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA, USA.
Fundação Oswaldo Cruz. Presidência. Centro de Relações Internacionais em Saúde. Rio de Janeiro, RJ, Brasil.
Fundación para la Alimentación y Nutrición de Centro América y Panamá (INCAP), Guatemala City, Guatemala.
Section of Nutrition, Pediatrics, University of Colorado, Aurora, CO, USA.
Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, CA, USA.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
Section of Nutrition, Pediatrics, University of Colorado, Aurora, CO, USA.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departmento de Virologia e Terapias Experimentais. Recife, PE, Brasil / School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Director of Research Institute at Imbanaco Medical Center, Cali, Colombia.
Social, Statistical and Environmental Sciences, RTI International, Durham, NC, USA.
Programa de Pós-Graduação em Ciências da Saúde (PPGCS) da Universidade de Pernambuco, Microcephaly Epidemic Research Group, Recife, Brazil.
Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.
Ribeirão Preto Medical School, Ribeirão Preto, Brazil.
Instituto de Medicina Tropical Alexander von Humboldt and Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima, Peru.
Department of Pathobiological Sciences, University of Wisconsin, Madison, WI, USA.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Department of Epidemiology, Harvard Chan School of Public Health, Boston, MA, USA.
Social, Statistical and Environmental Sciences, RTI International, Durham, NC, USA.
Instituto de Medicina Tropical Alexander von Humboldt and Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima, Peru.
University of Puerto Rico, San Juan, Puerto Rico.
Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA, USA.
University of Puerto Rico, San Juan, Puerto Rico.
Maternal-Infant Studies Center (CEMI), San Juan, Puerto Rico.
Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis.
Centro Nacional de Diagnostico y Referencia, Complejo Nacional de Salud, Managua, Nicaragua.
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA, USA.
Fundação Oswaldo Cruz. Presidência. Centro de Relações Internacionais em Saúde. Rio de Janeiro, RJ, Brasil.
Fundación para la Alimentación y Nutrición de Centro América y Panamá (INCAP), Guatemala City, Guatemala.
Section of Nutrition, Pediatrics, University of Colorado, Aurora, CO, USA.
Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, CA, USA.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
Section of Nutrition, Pediatrics, University of Colorado, Aurora, CO, USA.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departmento de Virologia e Terapias Experimentais. Recife, PE, Brasil / School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Director of Research Institute at Imbanaco Medical Center, Cali, Colombia.
Social, Statistical and Environmental Sciences, RTI International, Durham, NC, USA.
Programa de Pós-Graduação em Ciências da Saúde (PPGCS) da Universidade de Pernambuco, Microcephaly Epidemic Research Group, Recife, Brazil.
Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.
Ribeirão Preto Medical School, Ribeirão Preto, Brazil.
Instituto de Medicina Tropical Alexander von Humboldt and Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima, Peru.
Department of Pathobiological Sciences, University of Wisconsin, Madison, WI, USA.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Department of Epidemiology, Harvard Chan School of Public Health, Boston, MA, USA.
Social, Statistical and Environmental Sciences, RTI International, Durham, NC, USA.
Instituto de Medicina Tropical Alexander von Humboldt and Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima, Peru.
University of Puerto Rico, San Juan, Puerto Rico.
Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA, USA.
University of Puerto Rico, San Juan, Puerto Rico.
Maternal-Infant Studies Center (CEMI), San Juan, Puerto Rico.
Abstract
Until recently, Zika virus (ZIKV) infections were considered mild and self-limiting. Since 2015, they have been associated with an increase in microcephaly and other birth defects in newborns. While this association has been observed in case reports and epidemiological studies, the nature and extent of the relationship between ZIKV and adverse pregnancy and pediatric health outcomes is not well understood. With the unique opportunity to prospectively explore the full spectrum of issues related to ZIKV exposure during pregnancy, we undertook a multi-country, prospective cohort study to evaluate the association between ZIKV and pregnancy, neonatal, and infant outcomes.
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