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ArtigoDireito Autoral
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2025-01-01
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- IOC - Artigos de Periódicos [12659]
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MYCOBACTERIUM TUBERCULOSIS LINEAGE 1 GENETIC DIVERSITY IN PARÁ, BRAZIL, SUGGESTS COMMON ANCESTRY WITH EAST-AFRICAN ISOLATES POTENTIALLY LINKED TO HISTORICAL SLAVE TRADE
Espoligotipagem
Linhagem 1
Sequenciação do genoma inteiro
Polimorfismos de nucleotídeo único
Evolução molecular
Spoligotyping
Lineage 1
Whole genome sequencing
Single-nucleotide polymorphisms
Molecular evolution
Autor(es)
Conceição, Emilyn Costa
Refregier, Guislaine
Gomes, Harrison Magdiner
Olessa-Daragon, Xavier
Coll, Francesc
Ratavonirina, Noël Harijaona
Rasolofo-Razanamparany, Voahangy
Lopes, Maria Luiza
van Soolingen, Dick
Rutaihwa, Liliana
Gagneux, Sebastien
Bollela, Valdes Roberto
Suffys, Philip Noel
Duarte, Rafael Silva
Lima, Karla Valéria Batista
Sola, Christophe
Refregier, Guislaine
Gomes, Harrison Magdiner
Olessa-Daragon, Xavier
Coll, Francesc
Ratavonirina, Noël Harijaona
Rasolofo-Razanamparany, Voahangy
Lopes, Maria Luiza
van Soolingen, Dick
Rutaihwa, Liliana
Gagneux, Sebastien
Bollela, Valdes Roberto
Suffys, Philip Noel
Duarte, Rafael Silva
Lima, Karla Valéria Batista
Sola, Christophe
Afiliação
Institut de Biologie Intégrative de la Cellule, I2BC, UMR9198, CEA, CNRS, Univ. Paris-Sud, Univ. Paris-Saclay. Gif-sur-Yvette cedex, France / Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Professor Paulo de Góes. Pós-Graduação. Rio de Janeiro, RJ, Brasil.
Institut de Biologie Intégrative de la Cellule, I2BC, UMR9198, CEA, CNRS, Univ. Paris-Sud, Univ. Paris-Saclay. Gif-sur-Yvette cedex, France.
Institut de Biologie Intégrative de la Cellule, I2BC, UMR9198, CEA, CNRS, Univ. Paris-Sud, Univ. Paris-Saclay. Gif-sur-Yvette cedex, France / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactéria. Rio de Janeiro, RJ, Brasil.
Institut de Biologie Intégrative de la Cellule, I2BC, UMR9198, CEA, CNRS, Univ. Paris-Sud, Univ. Paris-Saclay. Gif-sur-Yvette cedex, France.
London School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases. London, UK.
Institut de Biologie Intégrative de la Cellule, I2BC, UMR9198, CEA, CNRS, Univ. Paris-Sud, Univ. Paris-Saclay. Gif-sur-Yvette cedex, France / Institut Pasteur de Madagascar. Unité des Mycobactéries; Antananarivo, Madagascar.
Institut Pasteur de Madagascar. Unité des Mycobactéries; Antananarivo, Madagascar.
Instituto Evandro Chagas. Seção de Bacteriologia e Micologia. Ananindeua, PA, Brasil.
National Institute for Public Health and the Environment. Bilthoven, the Netherlands / Radboud University Nijmegen Medical Centre. Department of Medical Microbiology. Nijmegen, the Netherlands.
Swiss Tropical & Public Health Institute. Basel, Switzerland / University of Basel. Basel, Switzerland.
Swiss Tropical & Public Health Institute. Basel, Switzerland / University of Basel. Basel, Switzerland.
Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactéria. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Professor Paulo de Góes. Pós-Graduação. Rio de Janeiro, RJ, Brasil.
Instituto Evandro Chagas. Seção de Bacteriologia e Micologia. Ananindeua, PA, Brasil.
Institut de Biologie Intégrative de la Cellule, I2BC, UMR9198, CEA, CNRS, Univ. Paris-Sud, Univ. Paris-Saclay. Gif-sur-Yvette cedex, France / Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto, SP, Brasil.;
Institut de Biologie Intégrative de la Cellule, I2BC, UMR9198, CEA, CNRS, Univ. Paris-Sud, Univ. Paris-Saclay. Gif-sur-Yvette cedex, France.
Institut de Biologie Intégrative de la Cellule, I2BC, UMR9198, CEA, CNRS, Univ. Paris-Sud, Univ. Paris-Saclay. Gif-sur-Yvette cedex, France / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactéria. Rio de Janeiro, RJ, Brasil.
Institut de Biologie Intégrative de la Cellule, I2BC, UMR9198, CEA, CNRS, Univ. Paris-Sud, Univ. Paris-Saclay. Gif-sur-Yvette cedex, France.
London School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases. London, UK.
Institut de Biologie Intégrative de la Cellule, I2BC, UMR9198, CEA, CNRS, Univ. Paris-Sud, Univ. Paris-Saclay. Gif-sur-Yvette cedex, France / Institut Pasteur de Madagascar. Unité des Mycobactéries; Antananarivo, Madagascar.
Institut Pasteur de Madagascar. Unité des Mycobactéries; Antananarivo, Madagascar.
Instituto Evandro Chagas. Seção de Bacteriologia e Micologia. Ananindeua, PA, Brasil.
National Institute for Public Health and the Environment. Bilthoven, the Netherlands / Radboud University Nijmegen Medical Centre. Department of Medical Microbiology. Nijmegen, the Netherlands.
Swiss Tropical & Public Health Institute. Basel, Switzerland / University of Basel. Basel, Switzerland.
Swiss Tropical & Public Health Institute. Basel, Switzerland / University of Basel. Basel, Switzerland.
Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactéria. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Professor Paulo de Góes. Pós-Graduação. Rio de Janeiro, RJ, Brasil.
Instituto Evandro Chagas. Seção de Bacteriologia e Micologia. Ananindeua, PA, Brasil.
Institut de Biologie Intégrative de la Cellule, I2BC, UMR9198, CEA, CNRS, Univ. Paris-Sud, Univ. Paris-Saclay. Gif-sur-Yvette cedex, France / Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto, SP, Brasil.;
Resumo em Inglês
Lineage 1 (L1) is one of seven Mycobacterium tuberculosis complex (MTBC) lineages. The objective of this study
was to improve the complex taxonomy of L1 using phylogenetic SNPs, and to look for the origin of the main L1
sublineage prevalent in Para, Brazil. We developed a high-throughput SNPs-typing assay based on 12-L1-specific
SNPs. This assay allowed us to experimentally retrieve SNP patterns on nine of these twelve SNPs in 277 isolates
previously tentatively assigned to L1 spoligotyping-based sublineages. Three collections were used: Pará-Brazil
(71); RIVM, the Netherlands (102), Madagascar (104). One-hundred more results were generated in Silico using
the PolyTB database. Based on the final SNPs combination, the samples were classified into 11 clusters (C1-C11).
Most isolates within a SNP-based cluster shared a mutual spoligotyping-defined lineage. However, L1/EAI1-SOM
(SIT48) and L1/EAI6-BGD1 (SIT591) showed a poor correlation with SNP data and are not monophyletic. L1/
EAI8-MDG and L1/EAI3-IND belonged to C5; this result suggests that they share a common ancestor. L1.1.3/
SIT129, a spoligotype pattern found in SNPs-cluster C6, was found to be shared between Pará/Brazil and Malawi.
SIT129 was independently found to be highly prevalent in Mozambique, which suggests a migration history from
East-Africa to Brazil during the 16th–18th slave trade period to Northern Brazil.
Palavras-chave
Complexo Mycobacterium tuberculosisEspoligotipagem
Linhagem 1
Sequenciação do genoma inteiro
Polimorfismos de nucleotídeo único
Evolução molecular
Palavras-chave em inglês
Mycobacterium tuberculosis complexSpoligotyping
Lineage 1
Whole genome sequencing
Single-nucleotide polymorphisms
Molecular evolution
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