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FACTORS AFFECTING THE ELECTROCARDIOGRAPHIC QT INTERVAL IN MALARIA: A SYSTEMATIC REVIEW AND META-ANALYSIS OF INDIVIDUAL PATIENT DATA
Autor
Chan, Xin Hui S.
Win, Yan Naung
Haeusler, Ilsa L.
Tan, Jireh Y.
Loganathan, Shanghavie
Saralamba, Sompob
Chan, Shu Kiat S.
Ashley, Elizabeth A.
Barnes, Karen I.
Baiden, Rita
Bassi, Peter U.
Djimde, Abdoulaye
Dorsey, Grant
Duparc, Stephan
Hanboonkunupakarn, Borimas
Ter Kuile, Feiko O.
Lacerda, Marcus V. G.
Nasa, Amit
Nosten, François H.
Onyeji, Cyprian O.
Pukrittayakamee, Sasithon
Siqueira, André M.
Tarning, Joel
Taylor, Walter R. J.
Valentini, Giovanni
van Vugt, Michèle
Wesche, David
Day, Nicholas P. J.
Huang, Christopher L-H.
Brugada, Josep
Price, Ric N.
White, Nicholas J.
Win, Yan Naung
Haeusler, Ilsa L.
Tan, Jireh Y.
Loganathan, Shanghavie
Saralamba, Sompob
Chan, Shu Kiat S.
Ashley, Elizabeth A.
Barnes, Karen I.
Baiden, Rita
Bassi, Peter U.
Djimde, Abdoulaye
Dorsey, Grant
Duparc, Stephan
Hanboonkunupakarn, Borimas
Ter Kuile, Feiko O.
Lacerda, Marcus V. G.
Nasa, Amit
Nosten, François H.
Onyeji, Cyprian O.
Pukrittayakamee, Sasithon
Siqueira, André M.
Tarning, Joel
Taylor, Walter R. J.
Valentini, Giovanni
van Vugt, Michèle
Wesche, David
Day, Nicholas P. J.
Huang, Christopher L-H.
Brugada, Josep
Price, Ric N.
White, Nicholas J.
Afiliación
Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit. Bangkok, Thailand / University of Oxford. Nuffield Department of Medicine. Centre for Tropical Medicine and Global Health. Oxford, United Kingdom.
Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit. Bangkok, Thailand / Health and Diseases Control Unit. Naypyidaw, Myanmar.
University of Oxford. Nuffield Department of Medicine. Centre for Tropical Medicine and Global Health. WorldWide Antimalarial Research Network. Oxford, United Kingdom / University College London Great Ormond Street Institute of Child Health. London, United Kingdom.
Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit. Bangkok, Thailand.
Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit. Bangkok, Thailand / University of Oxford. Christ Church College. Oxford, United Kingdom.
Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit. Bangkok, Thailand.
Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit. Bangkok, Thailand / Singapore Armed Forces Medical Corps. Singapore.
Health and Diseases Control Unit. Naypyidaw, Myanmar / Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit. Vientiane, Lao.
University of Cape Town. Department of Medicine. Division of Clinical Pharmacology. Cape Town, South Africa / WorldWide Antimalarial Resistance Network. Cape Town, South Africa.
INDEPTH Network Secretariat. Accra, Ghana.
University of Abuja. Faculty of Clinical Sciences. Department of Internal Medicine. College of Health Sciences. Abuja, Nigeria.
University of Science Techniques and Technologies of Bamako. Faculty of Pharmacy. Department of Epidemiology of Parasitic Diseases. Malaria Research and Training Center. Bamako, Mali.
University of California San Francisco. Department of Medicine. San Francisco, California, United States of America.
Medicines for Malaria Venture. Geneva, Switzerland.
Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit. Bangkok, Thailand / University of Oxford. Christ Church College. Oxford, United Kingdom / Mahidol University. Faculty of Tropical Medicine. Department of Clinical Tropical Medicine. Bangkok, Thailand.
Liverpool School of Tropical Medicine. Department of Clinical Sciences. Liverpool, United Kingdom.
Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brasil / Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brasil.
Sun Pharmaceutical Industries Ltd. Gurgaon, Haryana, India.
Health and Diseases Control Unit. Naypyidaw, Myanmar / Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit. Shoklo Malaria Research Unit. Mae Sot, Thailand.
Obafemi Awolowo University. Faculty of Pharmacy. Ile-Ife, Nigeria.
Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit. Bangkok, Thailand / University of Oxford. Christ Church College. Oxford, United Kingdom / Mahidol University. Faculty of Tropical Medicine. Department of Clinical Tropical Medicine. Bangkok, Thailand / The Royal Society of Thailand. Dusit, Bangkok, Thailand.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brasil.
Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit. Bangkok, Thailand / University of Oxford. Nuffield Department of Medicine. Centre for Tropical Medicine and Global Health. Oxford, United Kingdom / University of Oxford. Nuffield Department of Medicine. Centre for Tropical Medicine and Global Health. WorldWide Antimalarial Research Network. Oxford, United Kingdom.
Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit. Bangkok, Thailand / University of Oxford. Nuffield Department of Medicine. Centre for Tropical Medicine and Global Health. Oxford, United Kingdom.
Corporate R&D Department. Rome, Italy.
University of Amsterdam. Amsterdam University Medical Centers. Location Academic Medical Center. Amsterdam, Netherlands.
Certara, Princeton. New Jersey, United States of America.
Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit. Bangkok, Thailand / University of Oxford. Nuffield Department of Medicine. Centre for Tropical Medicine and Global Health. Oxford, United Kingdom.
University of Cambridge. Physiological Laboratory. Cambridge, United Kingdom.
University of Barcelona. Cardiovascular Institute. Hospital Clinic. Barcelona, Spain.
Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit. Bangkok, Thailand / University of Oxford. Nuffield Department of Medicine. Centre for Tropical Medicine and Global Health. Oxford, United Kingdom / Charles Darwin University. Menzies School of Health Research. Global and Tropical Health Division. Darwin, NT, Australia.
Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit. Bangkok, Thailand / University of Oxford. Nuffield Department of Medicine. Centre for Tropical Medicine and Global Health. Oxford, United Kingdom.
Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit. Bangkok, Thailand / Health and Diseases Control Unit. Naypyidaw, Myanmar.
University of Oxford. Nuffield Department of Medicine. Centre for Tropical Medicine and Global Health. WorldWide Antimalarial Research Network. Oxford, United Kingdom / University College London Great Ormond Street Institute of Child Health. London, United Kingdom.
Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit. Bangkok, Thailand.
Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit. Bangkok, Thailand / University of Oxford. Christ Church College. Oxford, United Kingdom.
Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit. Bangkok, Thailand.
Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit. Bangkok, Thailand / Singapore Armed Forces Medical Corps. Singapore.
Health and Diseases Control Unit. Naypyidaw, Myanmar / Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit. Vientiane, Lao.
University of Cape Town. Department of Medicine. Division of Clinical Pharmacology. Cape Town, South Africa / WorldWide Antimalarial Resistance Network. Cape Town, South Africa.
INDEPTH Network Secretariat. Accra, Ghana.
University of Abuja. Faculty of Clinical Sciences. Department of Internal Medicine. College of Health Sciences. Abuja, Nigeria.
University of Science Techniques and Technologies of Bamako. Faculty of Pharmacy. Department of Epidemiology of Parasitic Diseases. Malaria Research and Training Center. Bamako, Mali.
University of California San Francisco. Department of Medicine. San Francisco, California, United States of America.
Medicines for Malaria Venture. Geneva, Switzerland.
Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit. Bangkok, Thailand / University of Oxford. Christ Church College. Oxford, United Kingdom / Mahidol University. Faculty of Tropical Medicine. Department of Clinical Tropical Medicine. Bangkok, Thailand.
Liverpool School of Tropical Medicine. Department of Clinical Sciences. Liverpool, United Kingdom.
Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brasil / Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brasil.
Sun Pharmaceutical Industries Ltd. Gurgaon, Haryana, India.
Health and Diseases Control Unit. Naypyidaw, Myanmar / Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit. Shoklo Malaria Research Unit. Mae Sot, Thailand.
Obafemi Awolowo University. Faculty of Pharmacy. Ile-Ife, Nigeria.
Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit. Bangkok, Thailand / University of Oxford. Christ Church College. Oxford, United Kingdom / Mahidol University. Faculty of Tropical Medicine. Department of Clinical Tropical Medicine. Bangkok, Thailand / The Royal Society of Thailand. Dusit, Bangkok, Thailand.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brasil.
Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit. Bangkok, Thailand / University of Oxford. Nuffield Department of Medicine. Centre for Tropical Medicine and Global Health. Oxford, United Kingdom / University of Oxford. Nuffield Department of Medicine. Centre for Tropical Medicine and Global Health. WorldWide Antimalarial Research Network. Oxford, United Kingdom.
Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit. Bangkok, Thailand / University of Oxford. Nuffield Department of Medicine. Centre for Tropical Medicine and Global Health. Oxford, United Kingdom.
Corporate R&D Department. Rome, Italy.
University of Amsterdam. Amsterdam University Medical Centers. Location Academic Medical Center. Amsterdam, Netherlands.
Certara, Princeton. New Jersey, United States of America.
Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit. Bangkok, Thailand / University of Oxford. Nuffield Department of Medicine. Centre for Tropical Medicine and Global Health. Oxford, United Kingdom.
University of Cambridge. Physiological Laboratory. Cambridge, United Kingdom.
University of Barcelona. Cardiovascular Institute. Hospital Clinic. Barcelona, Spain.
Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit. Bangkok, Thailand / University of Oxford. Nuffield Department of Medicine. Centre for Tropical Medicine and Global Health. Oxford, United Kingdom / Charles Darwin University. Menzies School of Health Research. Global and Tropical Health Division. Darwin, NT, Australia.
Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit. Bangkok, Thailand / University of Oxford. Nuffield Department of Medicine. Centre for Tropical Medicine and Global Health. Oxford, United Kingdom.
Resumen en ingles
Electrocardiographic QT interval prolongation is the most widely used risk marker for ventricular arrhythmia potential and thus an important component of drug cardiotoxicity assessments. Several antimalarial medicines are associated with QT interval prolongation. However, interpretation of electrocardiographic changes is confounded by the coincidence of peak antimalarial drug concentrations with recovery from malaria. We therefore reviewed all available data to characterise the effects of malaria disease and demographic factors on the QT interval in order to improve assessment of electrocardiographic changes in the treatment and prevention of malaria.
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