Author | Mietto, Bruno Siqueira | |
Author | Souza, Beatriz Junqueira de | |
Author | Rosa, Patricia Sammarco | |
Author | Pessolani, Maria Cristina Vidal | |
Author | Lara, Flavio Alves | |
Author | Sarno, Euzenir Nunes | |
Access date | 2020-04-27T18:42:59Z | |
Available date | 2020-04-27T18:42:59Z | |
Document date | 2020 | |
Citation | MIETTO, Bruno Siqueira et al. Myelin breakdown favours Mycobacterium leprae survival in Schwann cells. Cellular Microbiology, v. 22,p. 1-8, 2020. | pt_BR |
ISSN | 1462-5814 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/40997 | |
Description | Acesso aberto em 26/04/2020 - https://onlinelibrary.wiley.com/doi/full/10.1111/cmi.13128 | pt_BR |
Language | eng | pt_BR |
Publisher | Wiley 12 Months | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Processos de doenças | pt_BR |
Subject in Portuguese | Infecção | pt_BR |
Subject in Portuguese | Metabolismo | pt_BR |
Subject in Portuguese | Interação microbiano-célula | pt_BR |
Subject in Portuguese | Micobactérias | pt_BR |
Title | Myelin breakdown favours Mycobacterium leprae survival in Schwann cells | pt_BR |
Type | Article | pt_BR |
DOI | 10.1111/cmi.13128 | |
Abstract | Leprosy neuropathy is a chronic degenerative infectious disorder of the peripheral nerve caused by the intracellular obligate pathogen Mycobacterium leprae (M. leprae). Among all nonneuronal cells that constitute the nerve, Schwann cells are remarkable in supporting M. leprae persistence intracellularly. Notably, the success of leprosy infection has been attributed to its ability in inducing the demyelination phenotype after contacting myelinated fibres. However, the exact role M. leprae plays during the ongoing process of myelin breakdown is entirely unknown. Here, we provided evidence showing an unexpected predilection of leprosy pathogen for degenerating myelin ovoids inside Schwann cells. In addition, M. leprae infection accelerated the rate of myelin breakdown and clearance leading to increased formation of lipid droplets, by modulating a set of regulatory genes involved in myelin maintenance, autophagy, and lipid storage. Remarkably, the blockage of myelin breakdown significantly reduced M. leprae content, demonstrating a new unpredictable role of myelin dismantling favouring M. leprae physiology. Collectively, our study provides novel evidence that may explain the demyelination phenotype as an evolutionarily conserved mechanism used by leprosy pathogen to persist longer in the peripheral nerve. | pt_BR |
Affilliation | Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. Juiz de Fora, MG, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto Lauro de Souza Lima. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Disease processes | pt_BR |
Subject | Infection | pt_BR |
Subject | Metabolism | pt_BR |
Subject | Microbial–cell interaction | pt_BR |
Subject | Mycobacteria | pt_BR |
e-ISSN | 1462-5822 | |