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LYMPHOCYTE-DEPENDENT AND TH2 CYTOKINE-ASSOCIATED COLITIS IN MICE DEFICIENT IN WISKOTT-ALDRICH SYNDROME PROTEIN
Colite
Linfócitos
Citocinas Th2
Ratos deficientes
Colitis
Lymphocyte
Th2 Cytokine
Mice Deficient
Autor
Afiliación
Massachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA / Harvard Medical School. Department of Medicine. Boston, MA, USA.
Massachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA / Harvard Medical School. Department of Medicine. Boston, MA, USA / Lausanne Medical School. Department of Medicine Division of Gastroenterology and Hepatology. Lausanne, Switzerland.
Massachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA / Harvard Medical School. Department of Medicine. Boston, MA, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Massachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA / Harvard Medical School. Department of Medicine. Boston, MA, USA.
Hannover Medical School. Department of Pediatric Hematology/Oncology. Hannover, Germany.
National Institute of Health. Mucosal Immunity Section. Bethesda, Maryland, USA.
Massachusetts General Hospital. Center for the Study of Inflammatory Bowel Diseases. Division of Rheumatology, Allergy and Immunology. Boston, MA, USA / Harvard Medical School. Department of Medicine. Boston, MA, USA.
Massachusetts General Hospital. Immunopathology Unit. Boston, MA, USA / Harvard Medical School. Department of Pathology. Boston, MA, USA.
Massachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA / Harvard Medical School. Department of Pathology. Boston, MA, USA.
Massachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA / Harvard Medical School. Department of Medicine. Boston, MA, USA.
Massachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA / Harvard Medical School. Department of Medicine. Boston, MA, USA / Lausanne Medical School. Department of Medicine Division of Gastroenterology and Hepatology. Lausanne, Switzerland.
Massachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA / Harvard Medical School. Department of Medicine. Boston, MA, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Massachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA / Harvard Medical School. Department of Medicine. Boston, MA, USA.
Hannover Medical School. Department of Pediatric Hematology/Oncology. Hannover, Germany.
National Institute of Health. Mucosal Immunity Section. Bethesda, Maryland, USA.
Massachusetts General Hospital. Center for the Study of Inflammatory Bowel Diseases. Division of Rheumatology, Allergy and Immunology. Boston, MA, USA / Harvard Medical School. Department of Medicine. Boston, MA, USA.
Massachusetts General Hospital. Immunopathology Unit. Boston, MA, USA / Harvard Medical School. Department of Pathology. Boston, MA, USA.
Massachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA / Harvard Medical School. Department of Pathology. Boston, MA, USA.
Massachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA / Harvard Medical School. Department of Medicine. Boston, MA, USA.
Resumen en ingles
Controversy exists as to whether patients with inflammatory bowel disease have an underlying immunodeficiency. We have focused on a murine model of the Wiskott-Aldrich syndrome, an immunodeficiency in which autoimmunity can manifest in the form of an inflammatory bowel disease-like illness. Wiskott-Aldrich syndrome protein (WASP) deficiency in mice results in similar clinical features. Herein, we characterized the colitis in WASP-deficient mice.
Palabras clave en portugues
Síndrome de Wiskott-AldrichColite
Linfócitos
Citocinas Th2
Ratos deficientes
Palabras clave en ingles
Wiskott-Aldrich Syndrome ProteinColitis
Lymphocyte
Th2 Cytokine
Mice Deficient
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