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BRAZILIAN CLINICAL TRIAL OF UNIFORM MULTIDRUG THERAPY FOR LEPROSY PATIENTS: THE CORRELATION BETWEEN CLINICAL DISEASE TYPES AND ADVERSE EFFECTS
Multibacillary leprosy
Paucibacillary leprosy
Adverse effects
Therapeutics
Leprostatic agents
Mycobacterium leprae
Hansenostáticos
Doenças Transmissíveis
Progressão da Doença
Hanseníase Multibacilar
Hanseníase Paucibacilar
Colaboradores: Marcelo Távora Mira (PUC-Paraná); Dra. Maria Lúcia Fernandes Penna (UFF) e Dra. Sinésio Talhari (UNL-AM).
Author
Affilliation
Centro de Dermatologia Dona Libânia. Fortaleza, CE, Brasil.
Centro de Dermatologia Dona Libânia. Fortaleza, CE, Brasil.
Universidade Federal de Goiás. Goiânia, GO, Brasil.
Fundação Alfredo da Matta. Manaus, AM, Brasil.
Universidade Estadual do Ceará. Fortaleza, CE, Brasil.
Universidade Federal do Ceará. Fortaleza, CE, Brasil.
Universidade de Brasília. Faculdade de Medicina. Núcleo de Medicina Tropical. Brasília, DF, Brasil.
Centro de Dermatologia Dona Libânia. Fortaleza, CE, Brasil.
Universidade Federal de Goiás. Goiânia, GO, Brasil.
Fundação Alfredo da Matta. Manaus, AM, Brasil.
Universidade Estadual do Ceará. Fortaleza, CE, Brasil.
Universidade Federal do Ceará. Fortaleza, CE, Brasil.
Universidade de Brasília. Faculdade de Medicina. Núcleo de Medicina Tropical. Brasília, DF, Brasil.
Abstract
This study sought to verify the correlation between leprosy types and the adverse effects of treatment drugs. This quantitative, prospective, nested study was developed at the Dona Libânia Dermatology Centre in Fortaleza, Brazil. Data were collected from November 2007-November 2008. During this period, 818 leprosy patients were diagnosed and began treatment. Forty patients with tuberculoid leprosy (TT) were selected. Twenty patients followed a standard therapy of dapsone and rifampicin and 20 were administered dapsone, rifampicin and clofazimine (U-MDT). Twenty patients with borderline lepromatous (BL) and lepromatous leprosy (LL) were also selected and treated with U-MDT. All of the subjects received six doses. With the exception of haemolytic anaemia, there was a low incidence of adverse effects in all the groups. We did not observe any differences in the incidence of haemolytic anaemia or other side effects across groups of patients with TT, BL or LL treated with U-MDT.
Keywords
LeprosyMultibacillary leprosy
Paucibacillary leprosy
Adverse effects
Therapeutics
Leprostatic agents
DeCS
HanseníaseMycobacterium leprae
Hansenostáticos
Doenças Transmissíveis
Progressão da Doença
Hanseníase Multibacilar
Hanseníase Paucibacilar
Publisher
Instituto Oswaldo Cruz
Citation
GONCALVES, Heitor de Sá et al . Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, p. 74-78, dec. 2012. Supl. 1.DOI
10.1590/s0074-02762012000900013ISSN
0074-0276Notes
Gerson Oliveira Penna - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.Colaboradores: Marcelo Távora Mira (PUC-Paraná); Dra. Maria Lúcia Fernandes Penna (UFF) e Dra. Sinésio Talhari (UNL-AM).
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