Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/41503
Type
ArticleCopyright
Open access
Collections
- IOC - Artigos de Periódicos [12494]
Metadata
Show full item record
THE ROLE OF SHORT-CHAIN FATTY ACIDS FROM GUT MICROBIOTA IN GUT-BRAIN COMMUNICATION
Neuroinflamação
Micróbio intestinal
Ácidos graxos de cadeia curta
Neuroinflammation
Gut-brain axis
Gut microbiota
Short-chain fatty acids
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.
Abstract
A substantial body of evidence supports that the gut microbiota plays a pivotal role in
the regulation of metabolic, endocrine and immune functions. In recent years, there has
been growing recognition of the involvement of the gut microbiota in the modulation
of multiple neurochemical pathways through the highly interconnected gut-brain axis.
Although amazing scientific breakthroughs over the last few years have expanded our
knowledge on the communication between microbes and their hosts, the underpinnings
of microbiota-gut-brain crosstalk remain to be determined. Short-chain fatty acids
(SCFAs), the main metabolites produced in the colon by bacterial fermentation of dietary
fibers and resistant starch, are speculated to play a key role in neuro-immunoendocrine
regulation. However, the underlying mechanisms through which SCFAs might influence
brain physiology and behavior have not been fully elucidated. In this review, we outline the
current knowledge about the involvement of SCFAs in microbiota-gut-brain interactions.
We also highlight how the development of future treatments for central nervous system
(CNS) disorders can take advantage of the intimate and mutual interactions of the
gut microbiota with the brain by exploring the role of SCFAs in the regulation of
neuro-immunoendocrine function.
Keywords in Portuguese
Sistema nervoso centralNeuroinflamação
Micróbio intestinal
Ácidos graxos de cadeia curta
Keywords
Central nervous systemNeuroinflammation
Gut-brain axis
Gut microbiota
Short-chain fatty acids
Share