Author | Couto, Fábio David | |
Author | Albuquerque, Alessandra B. Lima | |
Author | Adorno, Elisângela Vitória | |
Author | Abbehusen, L. de Freitas | |
Author | Oliveira, J. L. B. de | |
Author | Reis, Mitermayer Galvão dos | |
Author | Gonçalves, Marilda de Souza | |
Access date | 2012-07-17T21:13:06Z | |
Available date | 2012-07-17T21:13:06Z | |
Document date | 2003 | |
Citation | COUTO, Fábio David et al. Alpha-Thalassemia 2, 3.7 kb deletion and hemoglobin AC heterozygosity in pregnancy: a molecular and hematological analysis. Clinical and Laboratory Haematology, v. 25, n. 1, p. 29-34, Feb. 2003. | pt_BR |
ISSN | 0141-9854 | |
URI | https://www.arca.fiocruz.br/handle/icict/4176 | |
Abstract in Portuguese | Alpha-Thalassemia is a synthesis hemoglobinopathy with a worldwide distribution. alpha-thalassemia-23.7kb (alpha-Thal23.7kb) was investigated by PCR and standard hematologic analysis techniques in 106 pregnant women - 53 heterozygous for hemoglobin (Hb) A and C (AC) and 53 homozygous for the normal Hb A (AA) with similar ages and race ancestry. Eleven (21%) of AC women were alpha-Thal23.7kb heterozygous and 1 (2%) was homozygous, while 12 AA women (23%) were heterozygous. In the AA group, the MCV differed among those with normal alpha genes and those with alpha-Thal23.7kb (P = 0.031). Statistical analysis of AC group patients with normal alpha genes and alpha-Thal23.7kb carriers showed differences in MCV (P = 0.001); MCH (P = 0.003) and Hb C concentrations (P = 0.011). Analysis of AA and AC group patients with normal alpha genes showed differences in RBC (P = 0.033), Hb concentration (P = 0.003) and MCHC (P < 0.0001). There were no statistically significant differences for any hematologic parameters between AC and AA group patients with the alpha-Thal23.7kb genotype. The AC alpha-Thal23.7kb homozygous women had low hematologic parameters. Serum ferritin levels were normal among the groups studied. These results emphasize the importance of diagnosis and follow-up of patients with hemoglobinopathy carriers during pregnancy in order to administer adequate therapy and avoid further complications for mothers and newborns. | pt_BR |
Language | eng | pt_BR |
Rights | open access | |
Title | Alpha-Thalassemia 2, 3.7 kb deletion and hemoglobin AC heterozygosity in pregnancy: a molecular and hematological analysis | pt_BR |
Type | Article | pt_BR |
Defense date | 2003 | |
Place of Defense | Salvador | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Maternidade Pública Tsylla Balbino. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
Subject | Hemoglobinopathies | pt_BR |
Subject | Hemoglobin C | pt_BR |
Subject | Pregnancy | pt_BR |
Subject | Thalassemia | pt_BR |
Subject | Hematologic parameters | pt_BR |
DeCS | Deleção de Sequência | pt_BR |
DeCS | Talassemia alfa/genética | pt_BR |
DeCS | Estudos de Casos e Controles | pt_BR |
DeCS | Grupos de Populações Continentais | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Testes Genéticos | pt_BR |
DeCS | Testes Hematológicos | pt_BR |
DeCS | Hemoglobina A | pt_BR |
DeCS | Hemoglobina C | pt_BR |
DeCS | Heterozigoto | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Gravidez | pt_BR |
DeCS | Talassemia alfa/diagnóstico | pt_BR |