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LABORATORY MOUSE & COVID-19 RESEARCH
Oliveira, Gabriel Melo de | Fecha del documento:
2020
Afiliación
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular . Rio de Janeiro, RJ, Brasil.
Resumen en ingles
SARS-CoV-2 (COVID-19) rapidly spread and led to an outbreak in China and then became a global health emergency.
The scientific community importance around the world is evident by investigation for new knowledge, treatments
and a vaccine against COVID-19. An important biomodel in this intense research is mouse lab. However, standard
murine models, currently available, are resilient to COVID-19 infection experimental. Thus, laboratory animal
science researchers’ mice transgenic (humanized) developed and enable this biomodel susceptible, therefore, able
to collaborate in efforts to control this tragic pandemic. In this review, the objective was to summarize, mainly by the
most important animal laboratories, specialized in breeding and genetic manipulation science and to demonstrate to
the researchers the possibilities of developing in vivo assays using the mouse lab biomodel in pre-clinical trials against
COVID-19.
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