Author | Ferreira, Camila Pontes | |
Author | Cariste, Leonardo de Moro | |
Author | Noronha, Isaú Henrique | |
Author | Durso, Danielle Fernandes | |
Author | Lannes-Vieira, Joseli | |
Author | Bortoluci, Karina Ramalho | |
Author | Ribeiro, Daniel Araki | |
Author | Golenbock, Douglas | |
Author | Gazzinelli, Ricardo Tostes | |
Author | Vasconcelos, José Ronnie Carvalho de | |
Access date | 2020-07-13T18:10:03Z | |
Available date | 2020-07-13T18:10:03Z | |
Document date | 2020 | |
Citation | FERREIRA, Camila Pontes et al. CXCR3 chemokine receptor contributes to specific CD8+ T cell activation by pDC during infection with intracellular pathogens. Plos Negl Trop Dis., v. 14, n. 6, e0008414, 22p, June 2020. | pt_BR |
ISSN | 1935-2727 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/42230 | |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Receptor de quimiocina CXCR3 | pt_BR |
Subject in Portuguese | CD8+ T cell activation | pt_BR |
Subject in Portuguese | Infecção | pt_BR |
Subject in Portuguese | Patógenos intracelulares | pt_BR |
Title | CXCR3 chemokine receptor contributes to specific CD8+ T cell activation by pDC during infection with intracellular pathogens | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.pntd.0008414 | |
Abstract | Chemokine receptor type 3 (CXCR3) plays an important role in CD8+ T cells migration during intracellular infections, such as Trypanosoma cruzi. In addition to chemotaxis, CXCR3 receptor has been described as important to the interaction between antigen-presenting cells and effector cells. We hypothesized that CXCR3 is fundamental to T. cruzi-specific CD8+ T cell activation, migration and effector function. Anti-CXCR3 neutralizing antibody administration to acutely T. cruzi-infected mice decreased the number of specific CD8+ T cells in the spleen, and those cells had impaired in activation and cytokine production but unaltered proliferative response. In addition, anti-CXCR3-treated mice showed decreased frequency of CD8+ T cells in the heart and numbers of plasmacytoid dendritic cells in spleen and lymph node. As CD8+ T cells interacted with plasmacytoid dendritic cells during infection by T. cruzi, we suggest that anti-CXCR3 treatment lowers the quantity of plasmacytoid dendritic cells, which may contribute to impair the prime of CD8+ T cells. Understanding which molecules and mechanisms guide CD8+ T cell activation and migration might be a key to vaccine development against Chagas disease as those cells play an important role in T. cruzi infection control. | pt_BR |
Affilliation | Universidade Federal de São Paulo. Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Universidade Federal de São Paulo. Departamento de Biociências. Santos, SP, Brasil. | pt_BR |
Affilliation | Universidade Federal de São Paulo. Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brasil. | pt_BR |
Affilliation | University of Massachusetts Medical School. Department of Medicine. Worcester, Massachusetts,USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal de São Paulo. Departamento de Ciências Biológicas. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Universidade Federal de São Paulo. Departamento de Biociências. Santos, SP, Brasil. | pt_BR |
Affilliation | University of Massachusetts Medical School. Department of Medicine. Worcester, Massachusetts,USA. | pt_BR |
Affilliation | University of Massachusetts Medical School. Department of Medicine. Worcester, Massachusetts,USA. | pt_BR |
Affilliation | Universidade Federal de São Paulo. Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brasil / Universidade Federal de São Paulo. Departamento de Biociências. Santos, SP, Brasil. | pt_BR |
Subject | CXCR3 chemokine receptor | pt_BR |
Subject | CD8+ T cell activation | pt_BR |
Subject | Infection | pt_BR |
Subject | Intracellular pathogens | pt_BR |
e-ISSN | 1935-2735 | |